Repeatability of dynamic 3D phase-resolved functional lung (PREFUL) ventilation MR Imaging in patients with chronic...

A previous study has demonstrated the feasibility of 3D phase-resolved functional lung (PREFUL) MRI in healthy volunteers and patients with chronic pulmonary disease. Before clinical use, the repeatability of the ventilation parameters derived from 3D PREFUL MRI must be determined.

To evaluate repeatability of 3D PREFUL and to compare with pulmonary functional lung testing (PFT).

Prospective.

Fifty-three healthy subjects and 13 patients with chronic obstructive pulmonary disease (COPD).

A prototype 3D stack-of-stars spoiled-gradient-echo sequence at 1.5 T.

Study participants underwent repeated MRI examination (median time interval between scans COPD/healthy subjects [interquartile range]: 7/0 days [6-8/0-0 days]) and one PFT carried out at the time of the baseline MRI. For 3D PREFUL, regional ventilation (RVent) and flow-volume loops were computed and rated by cross-correlation (CC). Also, ventilation time-to-peak (VTTP) was computed. Ventilation defect percentage (VDP) maps were obtained for RVent and CC.

Repeatability of 3D PREFUL parameters was evaluated using Bland-Altman analysis, coefficient of variation (COV) and intraclass correlation coefficient (ICC). The relation between 3D PREFUL and PFT measures (forced expiratory volume in 1 second (FEV₁ ) and forced vital capacity (FVC) was assessed using the Pearson correlation coefficient (r).

In healthy subjects and COPD patients, no significant bias (all P range: 0.09-0.77) and a moderate to good repeatability of RVent, VTTP, and VDP_RVent were found (COV range: 0.1%-18.2%, ICC range: 0.51-0.88). For CC and VDP_CC moderate repeatability was found (COV range: 0.6%-43.6%, ICC: 0.38-0.60). CC, VDP_RVent , and VDP_CC showed a good correlation with FEV₁ (all |r| > 0.58, all P < 0.05) and FEV₁ /FVC ratio (all |r| > 0.62, all P < 0.05).

3D PREFUL provided a good repeatability of RVent, VTTP, and VDP_RVent and moderate repeatability of CC and VDP_CC in healthy volunteers and COPD patients, and correlated well with FEV₁ and FEV₁ /FVC.

2 TECHNICAL EFFICACY STAGE: 2.