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Assessment of Correlation between Craniofacial Proportions and Genetic Indicators
Guneet Guram1, Junaid A Shaik2, Raghu Devanna3
1Department of Orthodontics, Faculty of Dental Sciences, SGT University, Gurugram, Haryana, India, Phone: +91 9443455987,
The Journal of Contemporary Dental Practice
|February 11, 2021
Summary
Genetic markers in estrogen receptors (ESR1 and ESR2) correlate with craniofacial dimensions. Specific genotypes were linked to variations in jaw relationships, mandibular length, and facial heights in orthodontic patients.
Area of Science:
- Genetics
- Orthodontics
- Craniofacial Biology
Background:
- Craniofacial morphology is influenced by genetic and environmental factors.
- Estrogen receptors (ESR1 and ESR2) play a role in skeletal development.
- Understanding genetic contributions can aid in personalized orthodontic treatment.
Purpose of the Study:
- To investigate the correlation between specific genetic indicators in ESR1 and ESR2 and craniofacial proportions.
- To assess the potential role of these genetic markers in variations of craniofacial measurements.
Main Methods:
- 128 orthodontic patients (ages 12-18) were analyzed.
- Lateral cephalograms were used to measure vertical and sagittal craniofacial parameters.
- DNA from saliva was analyzed for ESR1 (rs9340799, rs2234693) and ESR2 (rs4986938, rs1256049) genetic variations using real-time PCR.
Main Results:
- The ESR2 rs4986938 CC genotype showed a correlation with the S-N dimension and mandibular body length (Go-Pg).
- The ESR1 rs2234693 CC genotype was associated with reduced lower anterior facial height (ANS-Me).
- No significant correlation was found between other genotypes and craniofacial measurements.
Conclusions:
- Estrogen receptor genes (ESR1 and ESR2) may influence craniofacial dimensions.
- Genetic markers like rs4986938 and rs2234693 show potential links to specific craniofacial measurements.
- This supports the concept of a genetic basis for craniofacial variations relevant to orthodontics.
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