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Fabrication of Three-dimensional Paper-based Microfluidic Devices for Immunoassays
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Increasing the packing density of assays in paper-based microfluidic devices
Sajjad Rahmani Dabbagh, Elaina Becher1, Fariba Ghaderinezhad2
1Department of Biomedical Engineering, University of Connecticut, Storrs, Connecticut 06269, USA.
Biomicrofluidics
|February 11, 2021
Summary
Advanced fabrication methods for paper-based diagnostic devices enable higher assay packing density and reduced reagent use. These innovations aim to lower costs and improve accessibility for point-of-care testing in diverse settings.
Area of Science:
- Microfluidics
- Analytical Chemistry
- Materials Science
Background:
- Paper-based devices offer accessible point-of-care diagnostics, environmental analysis, and food monitoring, particularly in resource-limited settings.
- Current market penetration is hindered by fabrication costs, necessitating increased assay packing density and minimized reagent volumes.
Purpose of the Study:
- This review discusses fabrication methods to enhance packing density and create closely packed features in paper-based devices.
- The goal is to enable low-cost, mass-produced assays with minimized sample and reagent requirements.
Main Methods:
- The review focuses on fabrication techniques that facilitate the creation of closely packed features on paper substrates.
- Discussion includes methods for increasing assay density and enabling mass production.
Main Results:
- Emerging fabrication methods allow for higher packing densities of assays on paper-based devices.
- These techniques support the minimization of sample volumes, such as liquid biopsies, and assay reagents.
Conclusions:
- Advanced fabrication methods are crucial for reducing the cost of paper-based assays.
- Increased packing density and reagent minimization through these methods will drive wider adoption of paper-based diagnostic tools.
