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Related Concept Videos

Liver Regeneration01:24

Liver Regeneration

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The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
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Tissue Renewal without Stem Cells01:23

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After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
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The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
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Diseases of the Liver and Gallbladder01:26

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Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
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Esophageal Varices-II: Clinical Features and Management01:28

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Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
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[Features of surgical patients of COVID-19 patients].

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[Liver regeneration: solved and problem issues].

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Related Experiment Video

Updated: Nov 17, 2025

Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model
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Author Spotlight: Advancing Liver Regeneration Research through ALPPS Mouse Model

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[Liver regeneration: resolved and problem issues].

A N Plekhanov1,2, A I Tovarshinov1

  • 1Buryat State University, Ulan-Ude, Russia.

Khirurgiia
|February 11, 2021
PubMed
Summary

Researchers are exploring stem cells and gene therapy to enhance liver regeneration, offering a potential alternative to liver transplantation for patients with liver disease.

Keywords:
liverregenerationstem cellsstimulation

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Area of Science:

  • Hepatology
  • Regenerative Medicine
  • Molecular Biology

Background:

  • The liver possesses remarkable regenerative capabilities due to its unique anatomical and physiological characteristics.
  • Understanding the molecular mechanisms of liver regeneration is crucial for developing therapeutic strategies.
  • Traditional treatments for liver failure, such as transplantation, face limitations.

Purpose of the Study:

  • To explore the potential of stem cells in cell therapy and tissue engineering for liver regeneration.
  • To review advancements in gene therapy for enhancing liver regeneration.
  • To present these approaches as alternatives to liver transplantation.

Main Methods:

  • Review of current literature on molecular mechanisms of liver regeneration.
  • Analysis of stem cell applications in liver tissue engineering and cell therapy.
  • Evaluation of gene therapy strategies for promoting liver repair.

Main Results:

  • Molecular insights have enabled the development of methods to enhance natural liver regeneration.
  • Stem cell-based therapies show promise for liver repair and regeneration.
  • Gene therapy offers a novel approach to augment the liver's regenerative capacity.

Conclusions:

  • Stem cell therapy and gene therapy represent promising avenues for treating liver diseases.
  • These innovative approaches could potentially reduce the need for liver transplantation.
  • Further research is warranted to fully realize the therapeutic potential of these strategies.