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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles
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Characterization and Applications of Colloidal Systems as Versatile Drug Delivery Carriers for Parenteral
Lakshmi Prasanna Kolluru1,2, Prachi Atre3, Syed A A Rizvi4
1Vaccine Nanotechnology Laboratory, College of Pharmacy, Mercer University, 3001 Mercer University Drive, Atlanta, GA 30341, USA.
Pharmaceuticals (Basel, Switzerland)
|February 12, 2021
Summary
Micro/nano emulsions enhance solubility and permeability for parenteral drug delivery, enabling development of challenging Biopharmaceutics Classification System (BCS) II, III, and IV drug candidates.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery
- Colloid Science
Background:
- Parenteral formulation of poorly water-soluble new chemical entities (NCEs) presents significant challenges.
- Existing solubility enhancement techniques do not guarantee successful formulation for parenteral delivery.
- Biopharmaceutics Classification System (BCS) II, III, and IV drugs often face development hurdles due to poor solubility and/or permeability.
Purpose of the Study:
- To review the utility of biphasic micro/nano emulsion systems for parenteral drug delivery.
- To explore how these systems can overcome formulation challenges associated with NCEs.
- To discuss the potential of these systems for BCS II, III, and IV drug candidates.
Main Methods:
- Review of literature on biphasic micro/nano emulsion systems.
- Discussion of formulation strategies involving surfactants.
- Analysis of characterization, stability, and regulatory aspects.
Main Results:
- Micro/nano emulsions significantly increase drug solubility and cell membrane permeability.
- These systems are effective for a broader range of drug candidates, including BCS III and IV.
- Successful formulation requires careful consideration of surfactant selection and system properties.
Conclusions:
- Biphasic micro/nano emulsions offer a promising approach for parenteral delivery of challenging NCEs.
- Exploitation of BCS II, III, and IV drugs is feasible with advanced emulsion technologies.
- Further research into characterization, stability, and regulatory pathways is essential for clinical translation.
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