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Hepatocyte nuclear factor 1 beta: A perspective in cancer
Shubhra Chandra1,2, Srilakshmi Srinivasan1,2, Jyotsna Batra1,2
1Institute of Health and Biomedical Innovation and School of Biomedical Sciences, Australian Prostate Cancer Research Centre-Queensland, Queensland University of Technology, Brisbane, QLD, Australia.
Cancer Medicine
|February 13, 2021
Summary
Hepatocyte nuclear factor 1 beta (HNF1β) is crucial for embryonic organ development and its dysregulation is linked to various cancers. This review explores HNF1β
Area of Science:
- Molecular biology
- Developmental biology
- Oncology
Background:
- Hepatocyte nuclear factor 1 beta (HNF1β) is a homeobox transcription factor essential for embryonic development of the liver, kidney, and pancreas.
- Initially identified as a cause of maturity-onset diabetes of the young (MODY), HNF1β is now implicated in various cancers due to expression deregulation and genetic variations.
- HNF1β functions through homodimerization or heterodimerization with HNF1α.
Purpose of the Study:
- To review the multifaceted role of HNF1β in the development of diverse human cancers.
- To discuss the significance of HNF1β splice variants in oncogenesis.
- To explore the potential of HNF1β as a diagnostic and prognostic biomarker in cancer.
Main Methods:
- Literature review of studies investigating HNF1β function in embryonic development and cancer.
- Analysis of research on HNF1β expression patterns, genetic polymorphisms, and splice variants in various tumor types.
- Synthesis of data on HNF1β's role in cellular processes relevant to cancer progression.
Main Results:
- HNF1β plays a critical role in the embryonic development of key organs.
- Deregulation of HNF1β and its polymorphisms are associated with endometrial, prostate, ovarian, hepatocellular, renal, and colorectal cancers.
- Splice variants of HNF1β may also contribute to tumorigenesis.
Conclusions:
- HNF1β is a significant factor in both normal development and cancer pathogenesis.
- Altered HNF1β expression and its variants represent potential therapeutic targets and biomarkers for early cancer detection and patient stratification.
- Further research into HNF1β's precise mechanisms in cancer is warranted.
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