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Updated: Nov 17, 2025

An Intestinal Gut Organ Culture System for Analyzing Host-Microbiota Interactions
Published on: June 30, 2021
Bacterial Quorum-Sensing Systems and Their Role in Intestinal Bacteria-Host Crosstalk
1Department of Rheumatology and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Institute of Immunology and Inflammation, Sichuan University, Chengdu, China.
Abstract:
Quorum-sensing (QS) system is a rapidly developing field in which we are gradually expanding our understanding about how bacteria communicate with each other and regulate their activities in bacterial sociality. In addition to collectively modifying bacterial behavior, QS-related autoinducers may also be embedded in the crosstalk between host and parasitic microbes. In this review, we summarize current studies on QS in the intestinal microbiome field and its potential role in maintaining homeostasis under physiological conditions. Additionally, we outline the canonical autoinducers and their related QS signal-response systems by which several pathogens interact with the host under pathological conditions, with the goal of better understanding intestinal bacterial sociality and facilitating novel antimicrobial therapeutic strategies.
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