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Updated: Nov 17, 2025

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Modification of oncolytic adenovirus and its application in cancer therapy

Yin Liang1, Jian He1, Yongxiang Zhao1,2

  • 1National Center for International Research of Bio-targeting Theranostics, Guangxi Key Laboratory of Bio-targeting Theranostics, Collaborative Innovation Center for Targeting Tumor Diagnosis and Therapy, Guangxi Medical University, Nanning, Guangxi 530021, China.

Discovery Medicine
|February 17, 2021
PubMed

Insights

Oncolytic viruses replicate in tumor cells, offering a potential cancer treatment. Modifications to oncolytic adenoviruses improve safety and efficacy, enhancing their use in combination cancer therapy.

Area of Science:

  • Virology
  • Oncology
  • Biotechnology

Background:

  • Oncolytic viruses selectively replicate within tumor cells, leading to cancer cell lysis.
  • Oncolytic adenoviruses are utilized for their safety profile but face limitations in clinical settings.
  • Neutralizing antibodies can impede the efficacy of oncolytic adenovirus therapies.

Purpose of the Study:

  • To explore modifications of oncolytic adenoviruses to enhance therapeutic outcomes.
  • To improve the safety and oncolytic impact of adenovirus-based cancer treatments.
  • To mitigate the effects of neutralizing antibodies on adenovirus efficacy.

Main Methods:

  • Genetic engineering of adenoviruses to enhance tumor cell replication.
  • Strategies to improve adenovirus stability and reduce immunogenicity.
  • Investigating combination therapies involving modified oncolytic adenoviruses and other anti-cancer agents.

Main Results:

  • Modified adenoviruses demonstrate improved tumor cell lysis and safety.
  • Reduced susceptibility to neutralizing antibodies observed in engineered adenoviruses.
  • Synergistic anti-tumor effects when combining modified oncolytic adenoviruses with other therapeutics.

Conclusions:

  • Adenovirus modification is a promising strategy to overcome limitations in oncolytic virotherapy.
  • Enhanced oncolytic adenoviruses offer improved safety and efficacy for cancer treatment.
  • Combined application of modified oncolytic adenoviruses holds significant potential for synergistic tumor treatment.

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