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Area of Science:

• Cardiovascular Surgery
• Pediatric Cardiology
• Thoracic Surgery

Background:

• The ductus arteriosus is a vital fetal blood vessel connecting the pulmonary artery to the aorta.
• Patent ductus arteriosus (PDA) closure is crucial for symptomatic patients experiencing left-to-right shunting.
• Surgical intervention is a primary treatment for PDA when conservative measures fail.

Purpose of the Study:

• To evaluate the hospital outcomes of surgical patent ductus arteriosus (PDA) closure over a 19-year period.
• To analyze the evolution and trends of PDA surgical closure across three distinct eras (2001-2019).
• To assess the safety and efficacy of surgical PDA ligation in a large patient cohort.

Main Methods:

• A retrospective analysis of 901 patients who underwent isolated surgical PDA closure from August 2001 to July 2019.
• Data categorized into three eras: 2001-2007, 2008-2013, and 2014-2019 to track surgical advancements.
• Key outcomes including mortality, morbidity (e.g., chylothorax), mechanical ventilation duration, and hospital stay were analyzed.

Main Results:

• The study included 901 patients, with initial era patients being significantly older.
• Overall in-hospital mortality was 0.8%, and mortality for isolated PDA was 0.2%.
• Low rates of complications such as chylothorax (0.4%) and short durations for ventilation and hospital stays were observed.

Conclusions:

• Surgical patent ductus arteriosus (PDA) closure demonstrates favorable hospital outcomes with low morbidity and mortality.
• The study highlights the successful evolution of PDA surgical techniques over 19 years at the center.
• This analysis provides valuable insights into the long-term safety and effectiveness of surgical PDA ligation.