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Fetal liver hematopoiesis: from development to delivery
Kyle Lewis1,2,3, Momoko Yoshimoto4, Takanori Takebe5,6,7,8,9
1Center for Stem Cell & Organoid Medicine (CuSTOM), Cincinnati Children's Hospital Medical Center, Cincinnati, OH, 45229, USA.
Stem Cell Research & Therapy
|February 18, 2021
Summary
Understanding the fetal liver niche is key to expanding hematopoietic stem cells (HSCs) for treating blood diseases. This review explores developmental insights for ex vivo HSC expansion and cell culture advancements.
Area of Science:
- Stem cell biology
- Developmental biology
- Hematology
Background:
- Hematopoietic stem cell (HSC) transplantation is a vital therapy for hematological diseases.
- Donor availability limits HSC therapeutic applications.
- The fetal liver niche plays a crucial role in HSC development and expansion.
Purpose of the Study:
- To review the importance of the fetal liver niche in HSC expansion.
- To explore emerging approaches for ex vivo HSC generation and expansion.
- To leverage developmental principles for improved HSC therapies.
Main Methods:
- Literature review focusing on the fetal liver niche and HSC expansion.
- Discussion of pluripotent stem cell (PSC) culture and organoid models.
- Integration of engineering and systems biology approaches.
Main Results:
- The fetal liver niche is critical for natural HSC expansion during development.
- Ex vivo HSC expansion faces challenges but shows promise with advanced models.
- Understanding niche interactions aids controlled HSC maturation and expansion.
Conclusions:
- Harnessing fetal liver niche knowledge can advance ex vivo HSC expansion strategies.
- Developing complex cell or organoid models is crucial for generating expandable HSCs.
- Applying developmental principles offers a pathway to overcome HSC donor limitations and enhance transplantation therapies.
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