Related Experiment Video
Updated: Nov 17, 2025
08:06
Assessment of the Metabolic Effects of Isocaloric 2:1 Intermittent Fasting in Mice
Published on: November 27, 2019
9.2K
Impact of Intermittent Fasting on Lipid Profile-A Quasi-Randomized Clinical Trial
Naseer Ahmed1, Javeria Farooq1, Hasan Salman Siddiqi1
1Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
Frontiers in Nutrition
|February 18, 2021
Summary
Intermittent fasting significantly improved lipid profiles, including raising low HDL cholesterol, in South Asian adults. This dietary approach may offer cardiovascular protection and disease management benefits.
Area of Science:
- Cardiology
- Metabolic Health
- Nutritional Science
Background:
- Sub-optimal high-density lipoprotein (HDL) cholesterol is a key cardiovascular disease risk factor.
- South Asians exhibit a higher prevalence of low HDL compared to global populations.
- Intermittent fasting (IF) is an energy restriction method with potential to improve lipid profiles.
Observation:
- A 6-week quasi-experimental trial involved South Asian adults with low HDL.
- The intervention group practiced 12-hour daytime fasting thrice weekly.
- Control group maintained usual dietary habits.
Findings:
- Intermittent fasting led to significant reductions in body weight, BMI, and waist circumference.
- The IF group demonstrated significant improvements in total cholesterol, HDL, and LDL cholesterol levels.
- Significant interaction effects favored the IF group for body measurements and lipid profile improvements.
Implications:
- Intermittent fasting shows promise in improving lipid profiles and increasing HDL cholesterol.
- IF may serve as a valuable lifestyle intervention for cardiovascular disease prevention and management.
- This strategy could be beneficial for individuals at risk of or with existing cardiovascular disorders.
Related Concept Videos
01:24Metabolic States of the Body: Fasting and Starvation
2.2K
During the initial hours of fasting, the body uses up its glycogen stores as an energy source. Once these glycogen reserves are depleted, the body begins breaking down stored triglycerides and structural proteins. During this stage, glycerol becomes a key substrate for gluconeogenesis, while free fatty acids undergo beta-oxidation to provide energy for tissues, such as skeletal muscle. In the fasting state, the body spares protein breakdown as much as possible to conserve muscle and structural...
2.2K
01:25Blood Studies for Cardiovascular System III: Serum Lipid Profile
427
Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
427
01:20Lipid-Lowering Drugs: Statins and Miscellaneous Agents
1.1K
Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
1.1K
01:15Bioavailability Study Design: Healthy Subjects Versus Patients
60
Bioavailability studies are essential for evaluating a drug's therapeutic efficacy and understanding its absorption patterns under various physiological conditions. Conducting such studies on target patient populations provides more relevant data by simulating real-world disease states. However, practical challenges often necessitate the use of young, healthy adult volunteers as study subjects.Patients may exhibit altered drug absorption patterns due to the effects of the disease itself,...
60
01:24Overview of Lipid Metabolism
3.7K
Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...
3.7K
01:29Cholesterol: Significance and Regulation
1.0K
Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...
Considering cholesterol and...
1.0K