Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance

420
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
420
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

89
Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
89
Drug Concentration Versus Time Correlation01:15

Drug Concentration Versus Time Correlation

1.6K
The plasma drug concentration-time curve is a crucial tool in pharmacokinetics, representing the drug's concentration in plasma at different time intervals post-administration. This curve illustrates the drug's journey from absorption into the systemic circulation, distribution to body tissues, and eventual elimination through excretion or biotransformation.
Two pivotal parameters are the minimum effective concentration (MEC) and the minimum toxic concentration (MTC). The MEC is the...
1.6K
Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers01:12

Antiarrhythmic Drugs: Class III Agents as Potassium Channel Blockers

1.5K
Class III antiarrhythmic drugs are a group of medications that can prolong action potentials in the heart. They achieve this by blocking potassium channels or enhancing inward currents from sodium channels. However, these drugs have a unique property of "reverse use-dependence," which is most pronounced at slower heart rates and can lead to torsades de pointes—a specific type of arrhythmia. However, it is essential to note that excessive QT interval prolongation—a measure of...
1.5K
Time Course of Drug Effect01:14

Time Course of Drug Effect

2.4K
The progression of a drug's impact can be analyzed by examining both the concentration-time course and the effect-time course. The concentration-time course is determined by the drug's half-life and is influenced by factors such as its pharmacokinetics, including absorption, distribution, metabolism, and elimination. The effect of the drug is often related to its concentration in the plasma and is calculated using the maximum drug effect and the plasma concentration that generates 50...
2.4K
Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

649
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
649

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Microalbuminuria Predicts Elevated Right Ventricular Filling Pressure in Non-Obstructive Coronary Artery Disease.

Medical journal of the Islamic Republic of Iran·2025
Same author

Consistency of Blood Pressure Measurement Methods in Atrial Fibrillation.

Medical journal of the Islamic Republic of Iran·2025
Same author

The Role of Medications in Enhancing Patients' Overall Well-being and Quality of Life in Coronary Slow Flow syndrome: A Randomized Controlled Trial.

Medical journal of the Islamic Republic of Iran·2025
Same author

Comparison of Artemether Versus Quinine for the Treatment of Cerebral Malaria in Children: A Meta-Analysis of Randomized Controlled Trials.

Cureus·2025
Same author

Disruption and Adaptation of Antimicrobial Stewardship Programs in Iranian Hospitals During the COVID-19 Pandemic: A Descriptive Phenomenological Qualitative Study.

Cureus·2025
Same author

Eosinophil percentage and platelet counts: Association with in-hospital mortality in ST-segment elevated myocardial infarction.

ARYA atherosclerosis·2025

Related Experiment Video

Updated: Nov 17, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.0K

Opium-associated QT Interval Prolongation: A Cross-sectional Comparative Study.

Hamid R Javadi1, Seyed M Mirakbari2, Abbas Allami3

  • 1Department of Cardiology, Bu Ali Hospital, Qazvin University of Medical Sciences, Qazvin, Islamic Republic of Iran.

Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine
|February 19, 2021
PubMed
Summary

Opium consumption is linked to a higher prevalence of QT interval prolongation, a potentially serious heart rhythm disturbance. This finding highlights the need for further research into the clinical significance of opium use.

Keywords:
OpioidsOpiumQT intervalQT prolongation

More Related Videos

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
08:28

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Published on: April 5, 2011

18.0K
Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

12.9K

Related Experiment Videos

Last Updated: Nov 17, 2025

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry

Published on: April 23, 2019

10.0K
Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus
08:28

Methods for ECG Evaluation of Indicators of Cardiac Risk, and Susceptibility to Aconitine-induced Arrhythmias in Rats Following Status Epilepticus

Published on: April 5, 2011

18.0K
Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
09:38

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery

Published on: April 14, 2016

12.9K

Area of Science:

  • Cardiology
  • Clinical Electrophysiology
  • Pharmacology

Background:

  • Long-term opioid use is well-studied for toxicity, but electrophysiological disturbances are less understood.
  • Emerging evidence suggests QT prolongation with opioid use, raising concerns for opium users, especially during the COVID-19 pandemic.

Purpose of the Study:

  • To determine the prevalence of QTc prolongation in opium users compared to non-users.
  • To investigate factors associated with QTc prolongation in opium users.

Main Methods:

  • A cross-sectional comparative study involving 123 opium users and 39 controls.
  • Comparison of median QTc intervals, gender, and age between groups.
  • Analysis of dose and duration of opium consumption in relation to QTc intervals.

Main Results:

  • Opium users exhibited a significantly higher median QTc interval (460 ms) than non-users (386 ms) (p < 0.001).
  • QTc prolongation was observed in 59.3% of opium users, versus 0% in controls (p < 0.001).
  • No significant association was found between QTc prolongation and the dose or duration of opium use.

Conclusions:

  • Opium consumption is associated with a significant increase in QTc prolongation.
  • The degree of QTc prolongation is independent of the dose and duration of opium use.
  • Further studies are recommended to evaluate the clinical implications and comparative risks of opium-induced QTc prolongation.