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A cerium oxide@metal-organic framework nanoenzyme as a tandem catalyst for enhanced photodynamic therapy
Jintong Liu1, Lin Yao Ye2, Wei Hong Xiong2
1Department of Chemistry, College of Sciences, Nanjing Agricultural University, Nanjing 210095, P. R. China. hongyang@njau.edu.cn and State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China. jpl@nju.edu.cn.
Abstract:
An O2 self-evolving core-shell theranostic nanohybrid was developed by encapsulating a nanoenzyme cerium oxide (CeOx) in a metal-organic framework (MOF). The hybrid reveals a 9-fold higher apoptotic percentage than bare CeOx in a harsh hypoxic microenvironment through tandem homogenous catalysis. Simultaneously, the oxygen-promoted therapeutic efficiency was self-monitored by the hybrid with caspase-3 activation, paving the way for MOF-functionalized nanoenzymes in theranostics.
