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Developing National Genotype-Independent Indicators for Recent Mycobacterium Tuberculosis Transmission Using

Alexia V Harrist1, Clinton J McDaniel1, Jonathan M Wortham1

  • 1National Center for HIV/AIDS, Viral Hepatitis, STD, and TB Prevention, Centers for Disease Control and Prevention, Atlanta, GA, USA.

Public Health Reports (Washington, D.C. : 1974)
|February 19, 2021
PubMed

Insights

Pediatric tuberculosis (TB) cases signal community transmission. New indicators using routine surveillance data can identify high-risk counties for TB, even without genotyping.

Area of Science:

  • Public Health
  • Epidemiology
  • Infectious Disease Surveillance

Background:

  • Pediatric tuberculosis (TB) cases are crucial indicators of recent Mycobacterium tuberculosis transmission.
  • Current genotyping methods often fail to identify pediatric TB cases due to a lack of culture positivity.

Purpose of the Study:

  • To develop and evaluate indicators for identifying ongoing TB transmission using pediatric TB case data.
  • To assess the feasibility of using routine surveillance data in the absence of genotyping.

Main Methods:

  • Developed three indicators: pediatric TB case proportion, pediatric TB case rate, and a statistical model for increased pediatric cases.
  • Analyzed US counties with pediatric TB cases from 2009-2017.
  • Compared indicator results against a list of known pediatric TB transmission events.

Main Results:

  • Case proportion and case rate indicators identified a large majority of counties with pediatric TB.
  • The statistical model identified 40 counties with significant increases in pediatric TB cases.
  • All counties with known multi-pediatric TB transmission events were flagged by at least one indicator; 23 were identified by all three.

Conclusions:

  • Routine TB surveillance data can effectively identify counties with potential ongoing TB transmission.
  • These indicators provide a feasible method for detecting transmission events, especially when genotyping data is unavailable.
Abstract

Keywords:
indicatorpediatric tuberculosistransmission

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