Noteworthy Cardiovascular Involvement with Sporadic Late-onset Nemaline Myopathy.

Area of Science:

• Cardiology
• Neurology
• Rare Diseases

Background:

• Sporadic late-onset nemaline myopathy (SLONM) is a rare neuromuscular disorder.
• Cardiac involvement is an emerging concern in SLONM.
• Understanding SLONM's cardiovascular manifestations is crucial for patient management.

Observation:

• A 66-year-old woman presented with recurrent cardiac arrest, right ventricular failure, and pulmonary hypertension.
• Despite pacemaker implantation and positive airway pressure, her cardiac symptoms persisted.
• Diagnosis of SLONM was confirmed via muscle biopsy.

Findings:

• The patient's primary symptoms were indicative of significant cardiovascular compromise.
• SLONM was the underlying cause of the severe cardiac manifestations.
• Right ventricular failure and pulmonary hypertension were prominent features.

Implications:

• This case underscores the potential for severe cardiac involvement in SLONM.
• It emphasizes the importance of cardiac evaluation in patients with unexplained heart failure and arrhythmias.
• Early recognition and management of cardiovascular complications may improve outcomes for SLONM patients.