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Arthritis as an initial presentation of malignancy: two case reports
Benjamin Sachdev Manjit Singh1, Sharifah Aishah Wan1, Yaw Kiet Cheong1
1Rheumatology Unit, Department of Medicine, Sarawak General Hospital, Kuching, Malaysia.
Journal of Medical Case Reports
|February 23, 2021
Summary
Paraneoplastic arthritis, a rare manifestation of hidden cancer, often presents atypically and resists standard treatments. Early screening for occult malignancy is recommended for patients with unusual arthritis symptoms.
Area of Science:
- Rheumatology
- Oncology
- Internal Medicine
Background:
- Paraneoplastic arthritis, a rare manifestation of occult malignancy, presents diagnostic challenges.
- Two cases illustrate paraneoplastic arthritis associated with lung adenocarcinoma and ovarian carcinoma.
Purpose of the Study:
- To highlight the atypical presentation and poor response to conventional therapy in paraneoplastic arthritis.
- To emphasize the importance of considering occult malignancy in patients with unexplained arthritis.
Main Methods:
- Case report analysis of two patients with paraneoplastic arthritis.
- Review of clinical presentation, diagnostic workup, and treatment outcomes.
Main Results:
- Patient 1: Oligoarthritis resolved with treatment for lung adenocarcinoma.
- Patient 2: Polyarthritis resolved following chemotherapy for ovarian carcinoma.
- Both cases showed poor response to initial rheumatologic treatments.
Conclusions:
- Paraneoplastic arthritis typically presents atypically and is refractory to disease-modifying antirheumatic drugs.
- Screening for occult malignancy is crucial in patients with atypical arthritis presentations.
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