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Emerging Therapeutic Applications for Fumarates.

Ayla Hoogendoorn1, Thomas D Avery2, Jiahe Li3

  • 1Vascular and Heart Health, Life Long Health Theme, South Australian Health and Medical Research Institute, Adelaide, Australia; ARC Centre of Excellence for Nanoscale BioPhotonics, The University of Adelaide, Australia.

Trends in Pharmacological Sciences
|February 23, 2021
PubMed
Summary
This summary is machine-generated.

Fumarates show promise beyond psoriasis and multiple sclerosis due to their antioxidant and anti-inflammatory effects. Further research into their mechanisms and optimized use is key for repurposing these drugs for new conditions.

Keywords:
atherosclerosisfumaratesischemia-reperfusion injuryneurodegenerative diseaseneuropathic pain

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Area of Science:

  • Pharmacology
  • Immunology
  • Neuroscience

Background:

  • Fumarates are established treatments for psoriasis and multiple sclerosis.
  • Their known antioxidative, immunomodulatory, and neuroprotective properties suggest broader therapeutic potential.
  • Understanding the precise mechanisms of action is crucial for drug repurposing.

Purpose of the Study:

  • To review the pharmacokinetics and pharmacodynamics of fumarates.
  • To discuss emerging applications of fumarates in neurological and cardiovascular diseases.
  • To highlight the importance of optimizing administration parameters for clinical use.

Main Methods:

  • Literature review of pharmacokinetic and pharmacodynamic studies on fumarates.
  • Analysis of recently FDA-approved fumarate medications (Vumerity™, Bafiertam™).
  • Synthesis of data on emerging therapeutic applications.

Main Results:

  • Fumarates possess properties suitable for treating various pathologies.
  • Optimizing administration route, dosage, timing, frequency, and duration is critical.
  • Emerging research indicates potential in neurological and cardiovascular disease treatment.

Conclusions:

  • Fumarates are versatile compounds with potential for repurposing beyond current indications.
  • Further elucidation of fumarate mechanisms and optimized clinical application is warranted.
  • Emerging data supports exploration in neurological and cardiovascular disease contexts.