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COVID-19 under 19: A meta-analysis

Nagham Toba1, Shreya Gupta1, Abdulrahman Y Ali1

  • 1College of Medicine, Mohammed Bin Rashid University of Medicine and Health Sciences, Dubai, United Arab Emirates.

Pediatric Pulmonology
|February 25, 2021
PubMed

Insights

This meta-analysis found that most pediatric COVID-19 cases were asymptomatic or mild. However, a significant portion of hospitalized children required intensive care, highlighting the need for continued research into pediatric COVID-19 clinical characteristics.

Area of Science:

  • Pediatric Infectious Diseases
  • Epidemiology
  • Public Health

Background:

  • The COVID-19 pandemic has significantly impacted global educational institutions.
  • Understanding pediatric COVID-19 clinical characteristics is crucial for effective management and public health strategies.

Purpose of the Study:

  • To conduct a meta-analysis of pediatric COVID-19 studies.
  • To review demographics, clinical manifestations, laboratory and radiological findings, treatments, and outcomes in children with COVID-19.

Main Methods:

  • A comprehensive meta-analysis of studies sourced from PubMed and Scopus.
  • Inclusion of 31 articles representing 1816 pediatric patients diagnosed between December 2019 and October 2020.
  • Utilized 95% confidence intervals for data analysis.

Main Results:

  • 19.2% of pediatric patients were asymptomatic; fever and cough were the most common symptoms.
  • Lymphopenia and leukopenia were frequent white blood cell abnormalities.
  • Ground glass opacities were the most common radiological finding; 96.3% hospitalization rate, with 10.8% ICU admissions and a 2.4% mortality rate.

Conclusions:

  • The majority of pediatric COVID-19 cases present with asymptomatic or mild symptoms.
  • A notable percentage of hospitalized children require intensive care.
  • Further research is recommended on multisystemic inflammatory syndrome in children (MIS-C).
Abstract

Keywords:
COVID-19SARS-CoV2adolescentschildrenclinical presentationmeta-analysispediatric

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