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Updated: Nov 16, 2025

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Solid-phase Submonomer Synthesis of Peptoid Polymers and their Self-Assembly into Highly-Ordered Nanosheets

Published on: November 2, 2011

Tabletized Supramolecular Assemblies for Sublingual Peptide Immunization.

Sean H Kelly¹, Emmanuel E Opolot¹, Yaoying Wu¹

¹Biomedical Engineering Department, Duke University, Durham, NC, 27708, USA.

Advanced Healthcare Materials

|February 26, 2021

Summary

This summary is machine-generated.

New heat-stable tablet vaccines administered under the tongue can improve global vaccine equity. This novel approach bypasses cold-chain needs and trained personnel, making vaccination more accessible worldwide.

Keywords:

biomaterials self-assembly sublingual tablets supramolecular assemblies vaccine

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Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Formation of Ordered Biomolecular Structures by the Self-assembly of Short Peptides

Published on: November 21, 2013

Area of Science:

Vaccinology
Biomaterials Science
Immunology

Background:

Global vaccine coverage is hindered by cold-chain and personnel requirements in low-resource settings.
Developing heat-stable, easily administered vaccines is crucial for health equity.

Purpose of the Study:

To describe a novel heat-stable, sublingually administered tablet vaccine (SIMPL).
To evaluate the immunogenicity and stability of SIMPL tablet vaccines.

Main Methods:

SIMPL tablets are created by freeze-drying self-assembling peptide-polymer nanofibers, sugars, and adjuvant.
Sublingual immunization was performed, and antibody responses were measured.
Tablet stability was assessed after heat exposure.

Main Results:

Sublingual SIMPL tablets successfully induced antibody responses against model and clinically relevant epitopes.
Antibody responses remained stable after heat treatment, unlike conventional vaccines.
The heat-stable nature of SIMPL tablets was confirmed.

Conclusions:

SIMPL tablet vaccines offer a promising heat-stable and easily deliverable alternative to conventional vaccines.
This technology can significantly improve vaccine accessibility and coverage in resource-limited regions.
Sublingual administration presents a viable strategy for global vaccination initiatives.