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Diagnostic and Prognostic Implications of Cardiac Markers for Hepatocellular Carcinoma
Mohan Krishna Ghanta1, Afzal Khan Akbar Khan1, L V K S Bhaskar2
1Department of Pharmacology, MVJ Medical College and Research Hospital, Bangalore-562114, Karnataka, India.
Insights
Hepatocellular carcinoma (HC) poses challenges due to late diagnosis and ineffective treatments. This review explores cardiac markers as potential early diagnostic and prognostic tools for liver cancer.
Area of Science:
- Hepatology
- Cardiology
- Biomarker Discovery
Background:
- Hepatocellular carcinoma (HC) is a primary liver cancer with poor outcomes, especially in advanced stages.
- Limited diagnostic and prognostic biomarkers exist for HC, hindering effective management.
- Cardiovascular events are implicated in HC progression, suggesting a link to cardiac markers.
Purpose of the Study:
- To review the association between cardiac markers and hepatocellular carcinoma (HC).
- To identify potential diagnostic and prognostic roles for cardiac markers in HC.
- To highlight research gaps concerning cardiac markers in HC for future studies.
Main Methods:
- Literature review of studies investigating cardiac markers in relation to HC.
- Analysis of HC pathology and its overlap with cardiovascular events like hypoxia.
- Identification of current scientific lacunae in the field.
Main Results:
- Cardiac markers may be associated with HC disease advancement.
- Certain cardiac markers could serve as potential diagnostic or prognostic indicators for HC.
- The review identifies a need for further research into these associations.
Conclusions:
- Cardiac markers represent a promising, yet under-explored, area for HC biomarker development.
- Further research is essential to validate cardiac markers for early HC diagnosis and prognosis.
- Cost-effective biomarkers are needed to improve HC patient survival and quality of life.
Abstract:
Hepatocellular carcinoma (HC) is a malignant primary liver cancer which has poor treatment outcomes in advanced stages, and many of the HC patients present with advanced stages. The incidence of death due to HC increase as a result of ineffective treatments for advanced stage disease. Early diagnosis and management has proven benefits in both survival and quality of life. Currently very few biomarkers are available to provide diagnostic and prognostic benefits in HC patients. The present review elaborates the association of cardiac markers in HC disease. The HC disease pathology includes many cardiovascular events like hypoxia and other parameters discussed in this review which have a role in disease advancement, and also may help as diagnostic and / or prognostic markers. The scientific lacuna in association / role of cardiac markers in HC disease is also stated in this review which may be helpful for future research studies and develop cost effective biomarker for early diagnosis of HC.
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