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Unmet Need in Essential Thrombocythemia and Polycythemia Vera
Ashwin Kishtagari1, Aaron T Gerds1
1Leukemia & Myeloid Disorders Program, Cleveland Clinic Taussig Cancer Institute, 9500 Euclid Avenue, CA60, Cleveland, OH 44120, USA.
Abstract:
Consensus guidelines have helped to standardize the care of patients with essential thrombocythemia and polycythemia vera, focusing on reducing the risk of thrombosis, mitigating symptoms, and avoiding therapies that may accelerate disease progression. However, many unmet needs still exist ranging from the roll of antiplatelet therapy in ET to medications that reduce disease progression. Retrospective studies suggest an improvement in myelofibrosis-free survival for treatment with interferons; new agents are looking to also enact disease modification.
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