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COVID-19: Molecular and Cellular Response

Shamila D Alipoor1, Esmaeil Mortaz2,3, Hamidreza Jamaati4

  • 1Molecular Medicine Department, Institute of Medical Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.

Frontiers in Cellular and Infection Microbiology
|March 1, 2021
PubMed

Insights

This review summarizes recent research on coronavirus disease 2019 (COVID-19) molecular features and immunopathogenesis. It provides insights for preventing and treating SARS-CoV-2 infection, referencing prior coronavirus studies.

Area of Science:

  • Virology
  • Immunology
  • Public Health

Background:

  • A novel coronavirus, SARS-CoV-2, emerged in Wuhan, China, causing a global pandemic.
  • Coronavirus disease 2019 (COVID-19) rapidly spread, declared a public health emergency by the WHO.
  • Understanding SARS-CoV-2 is critical due to its severe threat to human health.

Purpose of the Study:

  • To review recent advancements in COVID-19 molecular characteristics.
  • To summarize the immunopathogenesis of SARS-CoV-2 infection.
  • To offer a reference for future SARS-CoV-2 prevention and treatment strategies.

Main Methods:

  • Literature review of recent research on COVID-19.
  • Synthesis of findings on molecular features and immunopathogenesis.
  • Comparative analysis with SARS-CoV and MERS-CoV research.

Main Results:

  • Detailed summary of SARS-CoV-2 molecular biology.
  • Explanation of the immune response and pathogenesis in COVID-19.
  • Identification of knowledge gaps and research priorities.

Conclusions:

  • COVID-19 research is rapidly evolving.
  • Understanding molecular and immune aspects is key to control.
  • Further research is needed for effective prevention and treatment.

Keywords:
ACE2COVID-19IL-6IL-8cytokines

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