Related Experiment Video
Updated: Nov 15, 2025
03:40
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
Published on: December 20, 2024
927
Anti-IgE: A treatment option in allergic rhinitis?
Oliver Pfaar1, Francesca Gehrt1, Hansen Li1,2
1The two first authors have equally contributed to the publication.
Allergologie Select
|March 1, 2021
Summary
Omalizumab, an anti-IgE antibody, effectively controls allergic rhinitis (AR) symptoms and is safe for managing comorbidities. Further research into biologics for AR treatment is ongoing.
Area of Science:
- Immunology
- Allergology
- Pharmacology
Background:
- Allergic rhinitis (AR) is a prevalent IgE-mediated allergic condition.
- Omalizumab, an anti-IgE antibody, shows promise in AR treatment, with established use in asthma and urticaria.
- Currently, biologics lack approved indications for AR in Germany.
Purpose of the Study:
- To systematically review the efficacy and safety of omalizumab for allergic rhinitis treatment.
- To evaluate omalizumab's impact on symptom control and comorbidity management in AR patients.
Main Methods:
- A systematic literature review was conducted.
- Included studies comprised randomized controlled trials, meta-analyses, and reviews on omalizumab for AR.
Main Results:
- Strong evidence supports omalizumab's use in AR for symptom control.
- The review highlights a favorable safety profile for omalizumab in AR patients.
- Omalizumab effectively aids in managing comorbidities associated with AR.
Conclusions:
- Omalizumab presents a safe and effective treatment option for allergic rhinitis symptom control.
- It also demonstrates benefits in managing pre-existing comorbidities in AR patients.
- Further clinical trials investigating other biologics for AR are anticipated.
Related Concept Videos
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
1.5K
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
1.5K
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
1.2K
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
1.2K
01:17Drugs Used in Lower Respiratory Disorders: Overview
806
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
806
01:27Open Angle Glaucoma: Treatment
821
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
821
01:24Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF
290
Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab...
290
01:10Antibody Structure
62.9K
Overview
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
Antibodies, also known as immunoglobulins (Ig), are essential players of the adaptive immune system. These antigen-binding proteins are produced by B cells and make up 20 percent of the total blood plasma by weight. In mammals, antibodies fall into five different classes, which each elicits a different biological response upon antigen binding.
The Y-Shaped Structure of Antibodies Consists of Four Polypeptide Chains
Antibodies consist of four polypeptide chains: two identical heavy...
62.9K