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Urinary Biomarkers in Tumors: An Overview
Ilaria Cimmino1, Sara Bravaccini2, Claudio Cerchione3
1Department of Translational Medicine, University of Naples "Federico II", Naples, Italy.
Methods in Molecular Biology (Clifton, N.J.)
|March 2, 2021
Summary
Urine analysis offers a noninvasive method for detecting various cancers, including urogenital tumors. This liquid biopsy approach aids in identifying cancer biomarkers, improving diagnosis, and preventing overtreatment.
Area of Science:
- Urology
- Oncology
- Biomarker Discovery
Background:
- Urine is emerging as a valuable noninvasive tool for cancer detection.
- It serves as a liquid biopsy, containing crucial molecules like DNA, RNA, proteins, and exosomes.
- These components hold potential for identifying urogenital and nonurological tumors.
Purpose of the Study:
- To provide an overview of current urinary biomarkers for cancer.
- To discuss their potential in improving cancer prognosis, diagnosis, and treatment strategies.
- To highlight the limitations of using urine-based biomarkers.
Main Methods:
- Review of recent reports and ongoing research on urinary biomarkers.
- Analysis of diagnostic methodologies for detecting molecules in urine.
- Evaluation of the clinical utility and challenges of urine-based cancer detection.
Main Results:
- Urine contains a rich source of potential cancer biomarkers.
- Urinary biomarkers show promise for early cancer detection and monitoring.
- Several diagnostic techniques are being developed to analyze urine for cancer indicators.
Conclusions:
- Urine analysis represents a significant advancement in noninvasive cancer diagnostics.
- Further research is needed to overcome limitations and fully realize the potential of urinary biomarkers.
- Urinary biomarkers can aid in personalized cancer management and reducing overtreatment.
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