Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate02:21

Oxidation of Alkenes: Syn Dihydroxylation with Potassium Permanganate

14.8K
Alkenes can be dihydroxylated using potassium permanganate.  The method encompasses the reaction of an alkene with a cold, dilute solution of potassium permanganate under basic conditions to form a cis-diol along with a brown precipitate of manganese dioxide.
14.8K
Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide02:44

Oxidation of Alkenes: Syn Dihydroxylation with Osmium Tetraoxide

11.6K
Alkenes are converted to 1,2-diols or glycols through a process called dihydroxylation. It involves the addition of two hydroxyl groups across the double bond with two different stereochemical approaches, namely anti and syn. Dihydroxylation using osmium tetroxide progresses with syn stereochemistry.
11.6K
Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids02:04

Oxidation of Alkenes: Anti Dihydroxylation with Peroxy Acids

6.6K
Diols are compounds with two hydroxyl groups. In addition to syn dihydroxylation, diols can also be synthesized through the process of anti dihydroxylation. The process involves treating an alkene with a peroxycarboxylic acid to form an epoxide. Epoxides are highly strained three-membered rings with oxygen and two carbons occupying the corners of an equilateral triangle. This step is followed by ring-opening of the epoxide in the presence of an aqueous acid to give a trans diol.
6.6K
Oxidation of Alcohols02:37

Oxidation of Alcohols

14.5K
In this lesson, the oxidation of alcohols is discussed in depth. The various reagents used for oxidation of primary and secondary alcohols are detailed, and their mechanism of action is provided.
The process of oxidation in a chemical reaction is observed in any of the three forms:
14.5K
Redox Reactions01:24

Redox Reactions

57.5K
Oxidation-reduction or redox reactions involve the transfer of electrons from one molecule or atom to another. When an atom gains an electron, another atom must lose an electron, meaning oxidation and reduction must occur together. Since the redox occurs in pairs, the atom that gets oxidized is also called the reducing agent or reductant, and the atom that is reduced is also called the oxidizing agent or oxidant. A straightforward way to remember the definitions of oxidation and reduction is...
57.5K
Redox Reactions01:27

Redox Reactions

489
Redox reactions are vital biochemical processes that underpin energy metabolism in cells. These reactions involve the transfer of electrons between molecules, occurring in tandem as oxidation and reduction. Oxidation refers to the loss of electrons, while reduction denotes their gain. This coupling ensures the seamless flow of electrons through metabolic pathways. For example, in bacterial metabolism, glucose undergoes oxidation to carbon dioxide, while oxygen is simultaneously reduced to...
489

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanochemical Sulfur-Phenolate Exchange Click Reactions.

The Journal of organic chemistry·2026
Same author

Bimetallic-Node-Occupied MOF With Glycoside Hydrolase Activity for Efficient Bacterial Biofilm Hydrolysis.

Angewandte Chemie (International ed. in English)·2026
Same author

Electrochemical and Hydrolytic Stability of Bidentate Alkyne-Based Self-Assembled Monolayers on Gold: Effect of Head and Foot Chain Lengths.

Langmuir : the ACS journal of surfaces and colloids·2026
Same author

Glycocalyx micro- and nanodomains in cell-cell and cell-matrix interactions revealed by enhanced click chemistry.

Nature communications·2026
Same author

Terminal Conjugation Enables Nanopore Sequencing of Peptides.

Journal of the American Chemical Society·2026
Same author

Solid Additives Promote Side-Chain Ordering and Molecular Packing To Enhance the Performance of Organic Solar Cells.

The journal of physical chemistry letters·2025

Related Experiment Video

Updated: Nov 15, 2025

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

14.1K

Oxidation-Induced "One-Pot" Click Chemistry.

Bauke Albada1, Jordi F Keijzer1, Han Zuilhof1,2,3

  • 1Laboratory of Organic Chemistry, Wageningen University & Research, Stippeneng 4, 6807 WE Wageningen, The Netherlands.

Chemical Reviews
|March 4, 2021
PubMed
Summary
This summary is machine-generated.

Oxidation-induced click chemistry offers rapid, one-pot transformations for molecules and materials. This review highlights methods for generating reactive intermediates, enabling efficient synthesis of complex biomolecules and advanced materials.

More Related Videos

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
12:31

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Published on: August 19, 2012

25.2K
Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
07:36

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

8.2K

Related Experiment Videos

Last Updated: Nov 15, 2025

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

14.1K
Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry
12:31

Chemoselective Modification of Viral Surfaces via Bioorthogonal Click Chemistry

Published on: August 19, 2012

25.2K
Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy
07:36

Versatile CO2 Transformations into Complex Products: A One-pot Two-step Strategy

Published on: November 9, 2019

8.2K

Area of Science:

  • Organic Chemistry
  • Chemical Biology
  • Materials Science

Background:

  • Click chemistry is a powerful tool for molecular transformations due to its speed, efficiency, and compatibility.
  • Recent advances focus on oxidation-induced click reactions that generate reactive intermediates in situ from dormant precursors.
  • These methods offer rapid reaction rates and clean conversions, expanding click chemistry's utility.

Purpose of the Study:

  • To review oxidation-induced "one-pot" click chemistry methods.
  • To provide an overview of oxidation conditions compatible with click reactions.
  • To discuss the potential for sequential "click-oxidation-click" derivatizations.

Main Methods:

  • Literature review of oxidation-induced click chemistry strategies.
  • Analysis of oxidation conditions and their orthogonality to click reactions.
  • Examination of applications in small molecule, materials, and biomolecule transformations.

Main Results:

  • Oxidation-induced click chemistry enables some of the fastest click reactions.
  • Orthogonal oxidation conditions allow for sequential "click-oxidation-click" processes in one pot.
  • This strategy is effective for synthesizing high-performance materials and complex biomolecules.

Conclusions:

  • Oxidation-induced "one-pot" click chemistry is a rapidly emerging and powerful synthetic strategy.
  • The scope of these methods is expected to expand significantly in the future.
  • This approach facilitates the efficient preparation of advanced materials and intricate biomolecules.