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Nuclear fragility, blaming the blebs.

Nishit Srivastava1, Guilherme Pedreira de Freitas Nader1, Alice Williart1

  • 1Institut Curie and Institut Pierre Gilles de Gennes, PSL Research University, CNRS, UMR 144, Paris, France.

Current Opinion in Cell Biology
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Summary
This summary is machine-generated.

The cell nucleus changes shape under mechanical stress, leading to unstable nuclear envelope blebs. These blebs repeatedly open and close, causing mixing of nuclear and cell contents.

Keywords:
Cell nucleusNuclear blebsNuclear deformationNuclear envelopeNuclear envelope rupture.

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Area of Science:

  • Cell Biology
  • Biophysics
  • Mechanobiology

Background:

  • The cell nucleus, often depicted as oval, adopts diverse shapes in vivo.
  • Cellular deformation during migration or crowding imposes significant constraints on nuclear shape.

Purpose of the Study:

  • To review recent findings on nuclear fragility.
  • To highlight the phenomenon of nuclear envelope blebbing under mechanical stress.

Main Methods:

  • Literature review of studies on nuclear envelope dynamics.
  • Analysis of research on nuclear bleb formation and behavior.

Main Results:

  • Nuclear envelope blebs are distinct from plasma membrane blebs.
  • Nuclear blebs are unstable, leading to envelope opening and nucleocytoplasmic mixing.
  • Blebs repeatedly expand, burst, and repair under strong nuclear deformation.

Conclusions:

  • Nuclear blebs represent a significant source of nuclear instability.
  • Further research is needed to fully understand nuclear bleb formation and consequences.