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Related Concept Videos

Embryonic Stem Cells00:57

Embryonic Stem Cells

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Embryonic stem (ES) cells were first discovered in mice in 1981 by Martin Evans. In 1998, James Thomson identified a method to isolate embryonic stem cells from humans. Human embryonic stem cells (hESCs) are obtained from 3-5 day old embryos that remain unused after an in vitro fertilization procedure.
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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
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Updated: Nov 15, 2025

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Opportunities and challenges with stem cell-based embryo models.

Janet Rossant1, Patrick P L Tam2

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|March 5, 2021
PubMed
Summary
This summary is machine-generated.

Stem cell-based embryo models offer new ways to study mammalian development, aiding disease research and therapeutic advancements. High-fidelity models are crucial for ensuring biological relevance and clinical applicability.

Keywords:
amniotic sacblastoidsembryo modelsgastruloidshuman embryo developmentprimitive streakstem cells

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Area of Science:

  • Developmental biology
  • Stem cell research
  • Regenerative medicine

Background:

  • Mammalian embryogenesis involves complex processes like cell lineage differentiation, tissue morphogenesis, and organogenesis.
  • Understanding these developmental stages is key to addressing congenital diseases and improving regenerative therapies.

Purpose of the Study:

  • To explore the potential of stem cell-based embryo models for studying mammalian development.
  • To highlight the importance of high-fidelity models for biological and clinical relevance.

Main Methods:

  • Utilizing stem cell-derived embryo models.
  • Conducting experiments on these models to observe developmental processes.

Main Results:

  • Stem cell-based embryo models provide a powerful platform for investigating embryogenesis, differentiation, morphogenesis, and organogenesis.
  • These models facilitate functional genomic studies, disease mechanism elucidation, and therapeutic target identification.

Conclusions:

  • Stem cell embryo models represent a significant advancement in developmental biology and regenerative medicine.
  • Developing high-fidelity models is essential for translating research findings into clinically relevant applications and precision medicine.