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Updated: Nov 15, 2025
Quantifying the Antifungal Activity of Peptides Against Candida albicans
Published on: January 13, 2023
Antifungal activity of nikkomycin Z against Candida auris
Meghan L Bentz1, Natalie Nunnally, Shawn R Lockhart1
1Mycotic Diseases Branch, Centers for Disease Control and Prevention, 1600 Clifton Rd., Mailstop H17-2, Atlanta, GA30333, USA.
Background:
Nikkomycin Z is a competitive inhibitor of chitin synthase-an enzyme needed for synthesis of the fungal cell wall. Nikkomycin Z shows promise as a treatment for coccidioidomycoses and mixed activity has been described against other fungi and yeast. To our knowledge, it has not previously been tested against the emerging fungal pathogen Candida auris.
Objectives:
To determine the in vitro activity of nikkomycin Z against C. auris.
Methods:
Nikkomycin Z was tested by broth microdilution against a panel of 100 isolates of genetically diverse C. auris from around the world.
Results:
Nikkomycin Z showed mixed activity against the tested isolates, with an MIC range of 0.125 to >64 mg/L. The MIC50 and MIC90 were 2 and 32 mg/L, respectively.
Conclusions:
These findings suggest nikkomycin Z has in vitro activity against some, but not all isolates of C. auris.
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