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A High-throughput Platform for the Screening of Salmonella spp./Shigella spp.
Published on: November 7, 2018
Diagnostic syndromic multiplex approaches for gastrointestinal infections
Héctor Jesús Maldonado-Garza1, Elvira Garza-González1, Paola Bocanegra-Ibarias1
1Departamento de Medicina Interna, Universidad Autónoma De Nuevo León, Hospital Universitario Dr. José Eleuterio González Y Facultad De Medicina, Servicio De Gastroenterología, Monterrey, Nuevo León, Mexico.
Abstract:
Introduction: Gastrointestinal diseases due to infectious pathogens currently represent an important global health concern, especially in children and developing countries. Early and accurate detection of gastrointestinal pathogens is important to initiate the appropriate type of therapy. Multiplex molecular gastrointestinal panels rapidly detect several gastrointestinal pathogens at once with high sensitivity.Areas covered: We assess the scope and limitations of several multiplex gastrointestinal panels approved by the Food and Drug Administration or marked by Conformité Européenne-in vitro diagnostic. We compare 10 syndromic gastrointestinal panels, 14 bacteria-specific multiplex panels, seven parasite-specific multiplex panels, and eight virus-specific multiplex panels.Expert opinion: Thanks to the advances made in the diagnostic approaches for gastrointestinal infections, there are various panels to choose. The choice of a specific syndromic gastrointestinal multiplex panel should be made to improve patient care. Diagnostic syndromic multiplex approaches for gastrointestinal infections should be customized; each hospital should develop its diagnostic algorithm for gastrointestinal infections tailored to its setting, study population, and geographical site. Current multiplex gastrointestinal panels could be improved by including the detection of antimicrobial resistance, toxigenic Clostridioides difficile, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, the virus responsible for the COVID-19 pandemic).
Insights
Multiplex molecular gastrointestinal panels offer rapid, sensitive detection of various pathogens. Customizing diagnostic algorithms improves patient care, with future panels needing antimicrobial resistance and specific pathogen detection.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Molecular Diagnostics
Background:
- Gastrointestinal diseases caused by infectious pathogens are a significant global health issue, particularly affecting children and developing nations.
- Prompt and precise identification of gastrointestinal pathogens is crucial for effective treatment initiation.
- Multiplex molecular gastrointestinal panels provide a sensitive method for simultaneously detecting multiple pathogens.
Purpose of the Study:
- To evaluate the capabilities and constraints of various multiplex gastrointestinal panels available on the market.
- To compare syndromic, bacteria-specific, parasite-specific, and virus-specific multiplex panels.
Main Methods:
- Review and comparison of multiplex gastrointestinal panels approved by the FDA or CE-marked for in-vitro diagnostics.
- Analysis of 10 syndromic, 14 bacteria-specific, 7 parasite-specific, and 8 virus-specific multiplex panels.
Main Results:
- A diverse range of multiplex gastrointestinal panels are available due to advancements in diagnostic technology.
- The selection of a syndromic multiplex panel should prioritize enhancing patient care.
- Customized diagnostic algorithms for gastrointestinal infections are recommended, tailored to institutional needs and patient demographics.
Conclusions:
- Multiplex gastrointestinal panels represent a significant advancement in diagnosing gastrointestinal infections.
- Future multiplex panels could be enhanced by incorporating detection of antimicrobial resistance, toxigenic Clostridioides difficile, and SARS-CoV-2.
- Hospital-specific diagnostic algorithms are essential for optimizing the use of these panels.
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