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Updated: Nov 14, 2025

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
Pyridylacetic acids and related systems as alkylheteroarene surrogates in asymmetric decarboxylative Michael addition
Sebastian Frankowski1, Justyna Kowalska, Anna Albrecht
1Institute of Organic Chemistry, Faculty of Chemistry, Lodz University of Technology, Żeromskiego 116, 90-924 Łódź, Poland. anna.albrecht@p.lodz.pl.
Abstract:
In this manuscript, a novel method for the preparation of enantiomerically enriched pyridine derivatives has been described. It is based on the utilization of readily available 2-pyridylacetic acids as valuable synthons for the introduction of a pyridine ring in an asymmetric fashion. They have been used as pronucleophiles in asymmetric decarboxylative Michael addition to α,β-unsaturated aldehydes. The synthesis based on iminium activation using a chiral aminocatalyst that controlled the stereochemical outcome of the transformation has been successfully accomplished.
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