Enamel matrix derivative and subgingival reinstrumentation: a pilot study.

Area of Science:

• Periodontology
• Regenerative Dentistry
• Oral Health

Background:

• Supportive periodontal therapy (SPT) is crucial for managing periodontitis.
• Residual periodontal pockets can persist despite SPT, requiring intervention.
• Enamel matrix derivative (EMD) has shown potential in periodontal regeneration.

Purpose of the Study:

• To evaluate the efficacy of adjunctive enamel matrix derivative (EMD) during subgingival reinstrumentation in SPT.
• To assess the impact of EMD on clinical parameters and inflammatory markers in periodontal pockets.

Main Methods:

• A split-mouth design was employed in 13 patients with residual pockets (PD 5-8 mm).
• Teeth were treated with subgingival reinstrumentation, with or without EMD.
• Clinical variables (PD, CAL, BOP) and GCF cytokines (IL-1β, MMP-8, IL-10, TGF-β) were measured at baseline, 6, and 12 months.

Main Results:

• Both groups showed significant improvements in PD, CAL, and BOP.
• A significantly greater reduction in PD was observed in the EMD group after 12 months (P = .005).
• A significant difference in IL-1β change was noted between groups (P = .019).

Conclusions:

• Adjunctive EMD in subgingival reinstrumentation can lead to additional probing pocket depth reduction.
• This treatment modality may reduce the necessity for periodontal surgical interventions.
• EMD shows promise as an adjunct in managing persistent periodontal pockets during SPT.