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Nobiletin: Targeting the Circadian Network to Promote Bioenergetics and Healthy Aging
E Mileykovskaya1, S-H Yoo2, W Dowhan2
1Department of Biochemistry and Molecular Biology, The University of Texas Health Science Center at Houston, Houston, TX 77030. eugenia.mileykovskaya@uth.tmc.edu.
Biochemistry. Biokhimiia
|March 11, 2021
Summary
Nobiletin, a natural compound from citrus peels, activates the body's internal clock. This promotes healthy aging and may help treat age-related diseases.
Area of Science:
- Chronobiology
- Nutraceuticals
- Neurodegenerative disease research
Background:
- The circadian clock regulates daily bodily processes.
- Clock-modulatory agents, including natural compounds like nobiletin, are gaining interest for disease applications.
- Nobiletin, a flavonoid abundant in citrus peels, exhibits diverse biological activities, but its mechanism is unclear.
Purpose of the Study:
- To investigate the mechanism of action of nobiletin on the circadian clock.
- To evaluate the potential of nobiletin in promoting healthy aging and combating age-related diseases.
Main Methods:
- Unbiased chemical screening to identify nobiletin's interaction with the clock machinery.
- Utilizing animal models for diseases and aging studies.
- Assessing cellular energetics in peripheral tissues and the brain.
Main Results:
- Nobiletin was found to impinge on the clock machinery, activating temporal control of cellular processes.
- Beneficial effects of nobiletin on cellular energetics were observed in both periphery and brain.
- These effects contribute to promoting healthy aging.
Conclusions:
- Nobiletin modulates the circadian clock, impacting temporal control of cellular functions.
- Nobiletin demonstrates potent beneficial effects on cellular energetics, supporting healthy aging.
- With its safety profile, nobiletin is a promising candidate for nutraceutical and chronotherapeutic development against age-related neurodegenerative diseases.
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