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Updated: Nov 14, 2025

Efficient Synthesis of Polyfunctionalized Benzenes in Water via Persulfate-promoted Benzannulation of α,β-Unsaturated Compounds and Alkynes
Published on: December 16, 2019
Iodosobenzene-Mediated Three-Component Selenofunctionalization of Olefins
Zhi-Peng Liang1, Wei Yi1, Peng-Fei Wang1
1School of Pharmacy and Analysis & Testing Center, Nantong University, Nantong 226019, People's Republic of China.
Abstract:
A three-component reaction of olefin, diselenide and water, alcohols, phenol, carboxylic acid, or amine by a commercially available hypervalent iodine(III) reagent, PhIO, was developed. This method provides access to a wide range of vicinally functionalized selenoderivatives under ambient conditions with mostly excellent yields and high diastereoselectivity. The developed reaction displays high levels of functional group compatibility and is suitable for the late-stage functionalization of styrene-functionalized biomolecules. Preliminary investigations on the mechanism of the reaction are also presented.
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