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Tonsillitis I: Introduction01:30

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Substernal Thyroid Biopsy Using Endobronchial Ultrasound-guided Transbronchial Needle Aspiration
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Subacute Thyroiditis in COVID-19 Patients.

Saeed Sohrabpour1, Farrokh Heidari1, Ebrahim Karimi1

  • 1Otorhinolaryngology Research Center, Amir-Alam Hospital, Tehran University of Medical Sciences, Tehran, Iran.

European Thyroid Journal
|March 12, 2021
PubMed
Summary
This summary is machine-generated.

This study reports on six patients who developed subacute thyroiditis (SAT) following COVID-19 infection. Early diagnosis and steroid treatment were effective for this lesser-known COVID-19 complication.

Keywords:
2019-nCoVCOVID-19CoronavirusDe Quervain thyroiditisSubacute thyroiditis

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Area of Science:

  • Endocrinology
  • Infectious Diseases
  • Internal Medicine

Background:

  • Novel coronavirus (COVID-19) infection, first identified in late 2019, presents with respiratory symptoms.
  • The direct impact of coronaviruses on endocrine glands remains largely uncharacterized.
  • Subacute thyroiditis (SAT) is a known post-viral complication, but its association with COVID-19 is infrequently reported.

Purpose of the Study:

  • To describe cases of subacute thyroiditis (SAT) in patients with confirmed COVID-19 infection.
  • To highlight SAT as a potential, less recognized manifestation of COVID-19.
  • To present clinical, biochemical, and imaging findings in these patients.

Main Methods:

  • Case series reporting on six patients with clinical and biochemical evidence of SAT.
  • COVID-19 infection confirmed via positive serology tests (IgM and IgG).
  • Evaluation included physical examination, cervical ultrasonography, and laboratory tests (CRP, ESR, thyroid hormones, TSH).

Main Results:

  • Six patients (4 female, 2 male) presented with symptoms and signs consistent with SAT.
  • Cervical ultrasonography revealed bilateral hypoechoic thyroid areas suggestive of SAT.
  • Laboratory results showed elevated inflammatory markers, hyperthyroxinemia, and suppressed TSH, with positive COVID-19 serology and negative PCR tests.
  • Patients had occupational or familial exposure to COVID-19.
  • All patients responded well to steroid treatment during a 1-month follow-up.

Conclusions:

  • Subacute thyroiditis (SAT) is a potential endocrine complication following COVID-19 infection.
  • Physicians should consider SAT in patients with relevant symptoms and COVID-19 exposure history.
  • Prompt diagnosis and management, including steroid therapy, can effectively treat this condition and prevent further transmission.