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Clinical microdose study of gossypol: effect on sperm motility and renal function
J Frick1, W Aulitzky, N R Kalla
1Department of Urology, General Hospital Salzburg, Austria.
Contraception
|February 1, 1988
Abstract:
This study is part of a series designed to identify the smallest effective gossypol dose for male fertility control. Three men, aged 31-35 years, were administered gossypol, 10 mg/day, orally for 3 months. Urinalysis and assays for plasma hormone values, including cortisol, beta 2-microglobulin, potassium, and BUN, showed no changes during treatment. Forward sperm motility, however, was severely affected by the end of the treatment period (less than 4% forward motility). Sperm density also showed a marked decrease. The subjects developed no undue side effects.
Keywords:
AndrogensBiologyContraceptionContraceptive Agents, MaleContraceptive Agents--administraction and dosageEndocrine SystemEstradiolEstrogensExaminations And DiagnosesFamily PlanningFollicle Stimulating HormoneGenitaliaGenitalia, MaleGonadotropinsGonadotropins, PituitaryGossypol--administraction and dosageHormones--analysisLaboratory Examinations And DiagnosesLuteinizing HormonePhysiologyProlactinRenal EffectsReproductionSemen--analysisSeminal VesiclesSperm TransportTestosteroneUrogenital EffectsUrogenital System