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Updated: Nov 13, 2025

Synthetic Methodology for Asymmetric Ferrocene Derived Bio-conjugate Systems via Solid Phase Resin-based Methodology
Published on: March 12, 2015
Thioamide-Directed Cp*Co(III)-Catalyzed C-H Allylation of Ferrocenes
Zhuo-Zhuo Zhang1, Gang Liao2, Hao-Ming Chen2
1School of Food and Biological Engineering, Chengdu University, Chengdu, Sichuan 610106, China.
Abstract:
Herein, the first Cp*Co(III)-catalyzed C-H allylation of ferrocene thioamides with allyl carbonates has been developed. This reaction is compatible with a wide range of functional groups, providing various allylated ferrocene derivatives in up to 90% yields. In addition, the C-H allylation protocol is also compatible with the use of vinylcyclopropanes as allylating reagents by merging C-H and C-C activation into one catalytic system. Mechanistic studies revealed that the thiocarbonyl-directing group plays a vital role in C-H activation.
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