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Related Experiment Video

Updated: Nov 13, 2025

Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
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Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction

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Optimization of Prepectoral Breast Reconstruction.

Roberto Cuomo1, Francesco Ruben Giardino1, Alessandro Neri2

  • 1Unit of Plastic and Reconstructive Surgery, S. Maria Alle Scotte Hospital, Department of Medicine, Surgery, and Neuroscience, University of Siena, Siena, Italy.

Breast Care (Basel, Switzerland)
|March 15, 2021
PubMed
Summary

This study introduces an improved breast reconstruction technique using Braxon acellular dermal matrix (ADM) with prepectoral implants. The novel method significantly enhances aesthetic outcomes, particularly breast contour and upper pole definition, leading to greater patient satisfaction.

Keywords:
Acellular dermal matrixBraxonBreastBreast cancerBreast reconstruction

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Area of Science:

  • Plastic Surgery
  • Reconstructive Surgery
  • Biomaterials in Medicine

Background:

  • Acellular dermal matrix (ADM) has evolved, with Braxon® ADM enabling new breast reconstruction protocols since 2014.
  • Muscle-sparing techniques using ADM offer improved outcomes and reduced operative times.
  • Prepectoral implant placement is a key consideration in modern breast reconstruction.

Purpose of the Study:

  • To propose and evaluate a novel technique for breast reconstruction utilizing Braxon ADM with prepectoral implants.
  • To enhance the aesthetic results of breast reconstruction compared to traditional methods.
  • To assess the impact of the technique on specific aesthetic parameters like contour and upper pole definition.

Main Methods:

  • Patients underwent nipple skin-sparing mastectomy with modified subcutis preservation.
  • Aesthetic outcomes were compared between the novel Braxon ADM technique and traditional methods.
  • Statistical analysis included Student's t-test for mean values and the kappa test for interobserver agreement.

Main Results:

  • A significant improvement in overall aesthetic scores was observed in 29.6% of patients.
  • The most substantial improvement was noted in breast contour (+98.01%).
  • Statistically significant enhancements were found for contour, upper pole definition, and total aesthetic scores (p < 0.05).

Conclusions:

  • The proposed technique using Braxon ADM with prepectoral implants yields favorable aesthetic outcomes.
  • The study observed high patient satisfaction with the aesthetic results.
  • No major complications were reported in the small sample, supporting the technique's safety profile.