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Novel perspectives for SARS-CoV-2 genome browsing
1Ekofan Soğutma, Mugla, Turkey.
Journal of Integrative Bioinformatics
|March 15, 2021
Summary
A new genome browser for SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2) offers a consolidated view of viral variations and additional genomic data. This resource aids the scientific community in understanding and combating COVID-19.
Area of Science:
- Genomics
- Virology
- Bioinformatics
Background:
- Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has caused a global pandemic.
- Numerous SARS-CoV-2 genomes have been sequenced, revealing variations from the initial Wuhan reference.
- Existing genome browsers may not optimally represent these variations or include comprehensive genomic data.
Purpose of the Study:
- To develop a comprehensive genome browser for SARS-CoV-2.
- To provide a consolidated view of viral genome variations.
- To integrate additional relevant genomic information for researchers.
Main Methods:
- Alignment of over a hundred SARS-CoV-2 genomes.
- Generation of a consensus SARS-CoV-2 genome sequence.
- Development of a genome browser interface summarizing variations in a single track.
- Addition of predicted microRNAs (miRNAs), translation regulatory sequences (TRS), and secondary structure information as separate tracks.
Main Results:
- A consensus SARS-CoV-2 genome sequence was derived from aligned genomic data.
- A genome browser was created, displaying sequence variations efficiently.
- Predicted miRNAs, TRS, and secondary structures were successfully integrated into the browser alongside genomic variations.
Conclusions:
- A genome browser based on the SARS-CoV-2 consensus sequence provides a valuable resource for the scientific community.
- The browser's integrated data enhances the understanding of viral diversity and characteristics.
- This tool can aid global efforts in combating the COVID-19 pandemic.
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