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Myxoid liposarcoma: MRI features with histological correlation.

V M Encinas Tobajas1, C Almeida González2, D Marcilla3

  • 1Unidad de Gestión Clínica de Radiodiagnóstico, Hospital Universitario Virgen del Rocío, Sevilla, España.

Radiologia
|March 16, 2021
PubMed
Summary
This summary is machine-generated.

Magnetic resonance imaging (MRI) can help differentiate high-grade from low-grade myxoid liposarcomas. Specific MRI features, like lack of fat and heterogeneous enhancement, correlate with higher tumor grade, aiding clinical decisions.

Keywords:
HistologyHistologíaLiposarcomaLiposarcoma mixoideMagnetic resonance imagingMyxoid liposarcomaResonancia magnética

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Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • Myxoid liposarcoma is a sarcoma with adipose differentiation, but its behavior varies.
  • Accurate grading is crucial for treatment planning and prognosis.

Purpose of the Study:

  • To describe magnetic resonance imaging (MRI) features of myxoid liposarcomas.
  • To determine if MRI features correlate with histologic grade.
  • To assess MRI's ability to differentiate low-grade from high-grade myxoid liposarcomas.

Main Methods:

  • Retrospective analysis of 36 myxoid liposarcoma cases (2010-2018).
  • Evaluation of clinical and MRI features including size, borders, components, ADC values, and enhancement patterns.
  • Correlation of MRI findings with histologic grade and round cell percentage.

Main Results:

  • Tumors often occurred in young adults, predominantly in lower limbs.
  • Absence of fat, myxoid component <25%, non-fatty/non-myxoid component >50%, and heterogeneous enhancement were associated with high grade.
  • High ADC values were observed, but not significantly different between grades.

Conclusions:

  • MRI features can effectively distinguish between high-grade and low-grade myxoid liposarcomas.
  • MRI findings can assist clinicians in making informed treatment decisions for myxoid liposarcoma patients.