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Related Experiment Video

Updated: Jul 12, 2025

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
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Myxoid liposarcoma: MRI features with histological correlation.

V M Encinas Tobajas1, C Almeida González2, D Marcilla3

  • 1Unidad de Gestión Clínica de Radiodiagnóstico, Hospital Universitario Virgen del Rocío, Sevilla, Spain.

Radiologia
|October 20, 2023
PubMed
Summary
This summary is machine-generated.

Magnetic resonance imaging (MRI) can help differentiate between high- and low-grade myxoid liposarcomas. Specific MRI features, such as lack of fat and heterogeneous enhancement, are associated with higher tumor grades, aiding clinical decisions.

Keywords:
HistologyHistologíaLiposarcomaLiposarcoma mixoideMagnetic resonance imagingMyxoid liposarcomaResonancia magnética

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Area of Science:

  • Oncology
  • Radiology
  • Pathology

Background:

  • Myxoid liposarcoma is a common sarcoma with variable clinical behavior.
  • Accurate grading is crucial for effective treatment planning.
  • Distinguishing between low-grade and high-grade myxoid liposarcomas can be challenging.

Purpose of the Study:

  • To describe magnetic resonance imaging (MRI) features of myxoid liposarcomas.
  • To determine if MRI features correlate with histologic grade.
  • To assess MRI's utility in differentiating low-grade from high-grade myxoid liposarcomas for clinical decision-making.

Main Methods:

  • Retrospective analysis of 36 myxoid liposarcoma cases (2010-2018).
  • Evaluation of clinical and MRI features including size, composition, apparent diffusion coefficient (ADC), and contrast enhancement.
  • Correlation of MRI findings with histologic grade and percentage of round cells.

Main Results:

  • High-grade tumors were associated with absence of fat (69.6%), myxoid component <25% (100%), non-fatty/non-myxoid component >50% (83.3%), and heterogeneous enhancement (83.3%).
  • Tumor location was predominantly in lower limbs (97.2%), and most had well-defined borders (77.8%).
  • No significant association was found between ADC values and tumor grade.

Conclusions:

  • MRI features can effectively differentiate between high- and low-grade myxoid liposarcomas.
  • MRI findings provide valuable information for clinical decision-making in managing myxoid liposarcomas.