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Related Experiment Video

Updated: Nov 12, 2025

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling

Published on: July 26, 2017

Enhancing Inflammation Targeting Using Tunable Leukocyte-Based Biomimetic Nanoparticles.

Assaf Zinger^1,2, Manuela Sushnitha^1,2,3, Tomoyuki Naoi^1,2

¹Center for Musculoskeletal Regeneration, Houston Methodist Academic Institute, Houston, Texas 77030, United States.

|March 16, 2021

Summary

Researchers developed enhanced biomimetic nanoparticles by optimizing protein content for improved targeting of inflamed tissues. This advancement holds promise for more effective nanodelivery treatments for inflammatory conditions.

Keywords:

biomimicry cancer inflammation microfluidics nanoparticles

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Last Updated: Nov 12, 2025

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Area of Science:

Biomedical Engineering
Nanotechnology
Materials Science

Background:

Biomimetic nanoparticles mimic cellular behavior, like exosomes or leukocytes.
Leukocyte-based nanoparticles leverage cell membrane proteins for targeted delivery.
Optimizing protein integration is crucial for nanoparticle efficacy and in vivo behavior.

Purpose of the Study:

To investigate the impact of protein:lipid ratio on biomimetic nanoparticle properties and function.
To enhance the targeting capabilities of leukocyte-based biomimetic nanoparticles for inflamed endothelium.
To develop reproducible and effective nanodelivery platforms for inflammatory diseases.

Main Methods:

Utilized a microfluidic, bottom-up approach for nanoparticle synthesis.
Systematically tuned the protein:lipid ratio during synthesis.
Evaluated nanoparticle structural properties and in vivo targeting efficacy in animal models.

Main Results:

Increasing the protein:lipid ratio up to 1:20 (w/w) maintained nanoparticle structural integrity.
Higher protein content significantly improved nanoparticle targeting of inflamed endothelium.
Demonstrated enhanced targeting in two distinct animal models.

Conclusions:

Optimized protein content in biomimetic nanoparticles enhances their targeting of inflamed endothelium.
A microfluidic approach combined with parameter tuning yields reproducible, enhanced nanoparticles.
These nanoparticles show potential for improved nanodelivery in treating inflammatory conditions.