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Label-free Single Molecule Detection Using Microtoroid Optical Resonators
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Modular microring laser cavity sensor.

Lantian Chang, Michiel de Goede, Meindert Dijkstra

    Optics Express
    |March 17, 2021
    PubMed
    Summary
    This summary is machine-generated.

    We developed a novel modular microring laser (MML) cavity for biosensing. This new design offers superior flexibility, achieving a record-low limit of detection for optical sensors.

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    Area of Science:

    • Photonics
    • Optical Sensing
    • Biomedical Engineering

    Background:

    • Traditional ring cavities limit biosensor design due to coupled performance parameters.
    • Need for advanced optical sensing platforms with independent optimization capabilities.

    Purpose of the Study:

    • To propose and demonstrate a modular microring laser (MML) cavity for enhanced biosensing applications.
    • To decouple performance parameters for semi-independent optimization of biosensor design.

    Main Methods:

    • Fabrication and experimental testing of the first-generation MML sensor.
    • Characterization of key performance metrics including efficiency, temperature coefficient, and limit of detection (LOD).

    Main Results:

    • Achieved a fiber-to-fiber slope efficiency of up to 1.2%.
    • Measured a temperature coefficient of 1.35 GHz/K.
    • Demonstrated a record-low 3σ limit of detection (LOD) of 3.1 × 10-7 RIU (un-averaged) and 6.0 × 10-8 RIU (60s averaged).

    Conclusions:

    • The MML cavity provides significant design freedom for biosensor optimization.
    • The demonstrated MML sensor exhibits record-low LOD, outperforming existing on-chip ring cavity optical sensors.
    • The modular design allows for future optimization to meet specific sensing goals.