Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Development of Blood Vessels

Development of Blood Vessels

The development of the vascular system in a fetus is a complex and intricate process that begins as early as 15 to 16 days post-conception. This process starts outside the embryo, specifically in the mesoderm of the yolk sac, chorion, and connecting stalk. Approximately two days later, the formation of blood vessels occurs within the embryo itself.
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...

Autoregulation of Blood Flow

Autoregulation of Blood Flow

Autoregulation mechanisms are characterized by their inherent capacity for self-regulation without necessitating specific nervous stimulation or endocrine control. These mechanisms facilitate the adjustment of blood flow and, therefore, perfusion specific to each tissue region. This self-regulation encompasses chemical signals and myogenic controls.
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation....

Regulation of Angiogenesis and Blood Supply

Regulation of Angiogenesis and Blood Supply

Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Foot perfusion. Insights from an anatomically detailed arterial network model.

Journal of biomechanics·2026

Same author

A Modular Computational Approach for Assessing Active and Passive Force Contributions in Interstitial Lymphatic Fluid Uptake.

Annals of biomedical engineering·2026

Same author

A mechanistic approach for intracranial pressure (ICP) level estimation.

Scientific reports·2025

Same author

Cardiopulmonary mechanical interactions. Insights from an anatomically detailed arterial-venous network model.

Biomechanics and modeling in mechanobiology·2025

Same author

Intracranial pulse wave velocity using 4D flow MRI: method comparison and covariate analysis.

Interface focus·2025

Same author

Evaluating amplified magnetic resonance imaging as an input for computational fluid dynamics models of the cerebrospinal fluid.

Interface focus·2025

Same journal

Application of ephrin-B2 loaded glycol chitosan-silk fibroin hydrogel in the treatment of diabetic refractory wounds.

Scientific reports·2026

Same journal

International expert Delphi consensus on thromboprophylaxis in metabolic and bariatric surgery.

Scientific reports·2026

Same journal

Assessing the cross-region knowledge transfer capability of selected deep learning building vectorization methods in the context of available training datasets.

Scientific reports·2026

Same journal

Feasibility and preliminary effects of outdoor versus indoor cognitive-motor therapy in women with Alzheimer's disease: A randomized single-blind pilot study.

Scientific reports·2026

Same journal

Hallmarks of social action in the vocal turn-taking of wild common marmosets (Callithrix jacchus).

Scientific reports·2026

Same journal

Role and mechanism of AOPPs-induced NOX4-mediated ferroptosis in intervertebral disc degeneration.

Scientific reports·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Nov 12, 2025

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

Adaptive constrained constructive optimisation for complex vascularisation processes.

Gonzalo Daniel Maso Talou^1,2,3, Soroush Safaei⁴, Peter John Hunter⁴

¹Department of Mathematical and Computational Methods, National Laboratory for Scientific Computing, Petrópolis, Brazil. g.masotalou@auckland.ac.nz.

Scientific Reports

|March 18, 2021

Summary

This summary is machine-generated.

The adaptive Constrained Constructive Optimisation (CCO) algorithm enhances modeling of complex vascular networks. This new method improves anatomical accuracy in simulated vascular territories for better understanding of blood flow and cell function.

More Related Videos

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Published on: November 2, 2016

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Related Experiment Videos

Last Updated: Nov 12, 2025

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Stepwise Cell Seeding on Tessellated Scaffolds to Study Sprouting Blood Vessels

Published on: January 14, 2021

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

The Arteriovenous AV Loop in a Small Animal Model to Study Angiogenesis and Vascularized Tissue Engineering

Published on: November 2, 2016

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression

Published on: January 15, 2022

Area of Science:

Computational Biology
Biomedical Engineering
Mathematical Modeling

Background:

Understanding vascular territories is crucial for analyzing circulatory dynamics and blood flow-cell function coupling.
Existing algorithms for vascular network modeling require enhancement for complex architectures.

Purpose of the Study:

To extend the Constrained Constructive Optimisation (CCO) algorithm for complex automatic vascularisation tasks.
To improve the anatomical accuracy of modeled vascular networks using adaptive strategies.

Main Methods:

Integration of adaptive optimisation criteria and multi-staged space-filling strategies into the CCO algorithm.
Definition of vascular territory as a partition of vascular, avascular, and carriage domains.
Development of the aDaptive CCO (DCCO) algorithm enabling biologically-inspired vascularisation stages.

Main Results:

The DCCO algorithm enhances modeling capabilities for specific vascular architectures.
The multi-staged approach improves consistency with anatomical hierarchy.
The algorithm can initiate vascular outgrowth from scratch or existing networks.

Conclusions:

The DCCO algorithm offers improved anatomical accuracy in modeled vascular networks.
This advancement aids in analyzing multi-scale circulatory cascades and cell function.
The method is validated through anatomically realistic scenarios.