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Facile Preparation of 4-Substituted Quinazoline Derivatives
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Carbamate and N-Pyrimidine Mitigate Amide Hydrolysis: Structure-Based Drug Design of Tetrahydroquinoline IDO1

Derun Li1, Yongqi Deng1, Abdelghani Achab1

  • 1Departments of Discovery Chemistry, Pharmacokinetics, Pharmacodynamics, and Drug Metabolism, Computational and Structural Chemistry, Discovery Process Chemistry, Discovery Pharmaceutical Science, and Quantitative Biosciences, Merck & Co., Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States.

ACS Medicinal Chemistry Letters
|March 19, 2021
PubMed

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