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John Wooten1, Katie Benedyk2, Mehul Patel1
1Department of Emergency Medicine, UNC-Chapel Hill, Chapel Hill, NC, USA.
The American Journal of Emergency Medicine
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No abstract available in PubMed .
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Body:In certain scenarios, in vitro dissolution tests can replace in vivo bioequivalence studies. This is particularly true when a drug product, though available in varying strengths, maintains proportional similarity in its active and inactive ingredients. In such cases, the need for in vivo bioequivalence studies for lower strength variants may be waived, provided dissolution tests and in vivo studies on the highest strength yield satisfactory results.Bioequivalence can be indicated through...
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