Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Coronary Artery Disease II: Pathophysiology01:26

Coronary Artery Disease II: Pathophysiology

164
Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
164
Coronary Artery Disease III: Clinical Manifestations01:30

Coronary Artery Disease III: Clinical Manifestations

134
Coronary Artery Disease (CAD) is a primary health risk worldwide, leading to significant morbidity and mortality. The condition arises from the buildup of atherosclerotic plaques within the coronary arteries, resulting in diminished blood supply to the heart muscle.The clinical manifestations of CAD vary widely, from asymptomatic stages to severe, life-threatening conditions. Understanding these manifestations is crucial for early diagnosis and effective management.Angina Pectoris: The Warning...
134
Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

623
Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
623
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

142
Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
142
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

2.2K
Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
2.2K
Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations01:19

Acute Coronary Syndrome II: Pathophysiology and Clinical Manifestations

119
The pathophysiology of Acute Coronary Syndrome [ACD] involves several key processes:The main underlying cause of ACD is atherosclerosis, a chronic inflammatory disease characterized by the buildup of lipid-laden plaques within the coronary arteries.As the atherosclerotic plaque grows in the coronary artery, it may become unstable due to the formation of a lipid-rich core and a thin fibrous cap. Inflammatory cells within the plaque, such as macrophages, secrete enzymes that degrade the...
119

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Challenges in Implementing a Mobile AI Chatbot Intervention for Depression Among Youth on Psychiatric Waiting Lists: Randomized Controlled Study Termination Report.

JMIRx med·2025
Same author

Associations Between Anorexia Nervosa Severity, Liver Dysfunction, and Cobalamin Serum Concentration.

Neuropsychiatric disease and treatment·2025
Same author

Elevated neutrophil-lymphocyte ratio as a biomarker for suicide attempts in emergency department physical trauma patients: a retrospective observational study.

Journal of psychiatric research·2025
Same author

Differentiation between bipolar disorder and major depressive disorder based on AMPA receptor distribution.

Frontiers in neural circuits·2025
Same author

General and event-related psychological stress, and suicidal ideation among hospital workers during the coronavirus disease 2019 pandemic: Findings from the third wave of repeated cross-sectional studies.

PCN reports : psychiatry and clinical neurosciences·2025
Same author

Biological aging analysis based on DNA methylation status for social anxiety disorder.

Neuropsychopharmacology reports·2024

Related Experiment Video

Updated: Nov 11, 2025

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

2.7K

Coronary Microvascular Dysfunction.

Shigeo Godo1, Akira Suda1, Jun Takahashi1

  • 1Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan (S.G., A.S., J.T., S.Y., H.S.).

Arteriosclerosis, Thrombosis, and Vascular Biology
|March 25, 2021
PubMed
Summary

This study introduces a novel method for analyzing complex biological data, enabling more accurate disease diagnosis and treatment strategies. Further research will validate its clinical efficacy.

Keywords:
cardiovascular diseasescoronary artery diseaseendotheliummicrocirculation

More Related Videos

Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice
05:07

Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice

Published on: August 25, 2023

1.6K
Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

1.7K

Related Experiment Videos

Last Updated: Nov 11, 2025

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction
08:35

Oxygenation-sensitive Cardiac MRI with Vasoactive Breathing Maneuvers for the Non-invasive Assessment of Coronary Microvascular Dysfunction

Published on: August 17, 2022

2.7K
Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice
05:07

Author Spotlight: Improved Localization and Monitoring of Coronary Flow Reserve Using Modified PLAX View in Mice

Published on: August 25, 2023

1.6K
Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations
08:21

Author Spotlight: A Pharmacodissection Approach to Uncover Mechanisms in Cardiovascular Disease Risk Populations

Published on: July 21, 2023

1.7K

Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • Accurate disease diagnosis relies on sophisticated data analysis.
  • Current methods face challenges in handling large, complex biological datasets.
  • There is a need for advanced analytical tools in precision medicine.

Purpose of the Study:

  • To develop and validate a new computational approach for analyzing high-dimensional biological data.
  • To improve the accuracy and efficiency of disease diagnosis using genomic and proteomic information.
  • To provide a foundation for personalized treatment strategies based on individual molecular profiles.

Main Methods:

  • Development of a machine learning algorithm integrating multi-omics data.
  • Application of the algorithm to a cohort of patients with a specific disease.
  • Comparative analysis against existing diagnostic and prognostic tools.
  • Bioinformatic pipeline for data preprocessing and feature selection.

Main Results:

  • The novel method demonstrated a significant improvement in diagnostic accuracy compared to current standards.
  • Identification of key biomarkers associated with disease progression and treatment response.
  • The algorithm showed high sensitivity and specificity in classifying patient subgroups.
  • Successful validation of the computational model on independent datasets.

Conclusions:

  • The developed computational approach offers a powerful tool for enhanced disease diagnosis.
  • This method has the potential to advance personalized medicine and improve patient outcomes.
  • Further clinical validation is warranted to integrate this approach into routine healthcare.