Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Development of Immunocompetence01:22

Development of Immunocompetence

570
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
570
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

1.2K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
1.2K
Immunological Memory01:23

Immunological Memory

14.2K
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
14.2K
Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

627
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
627
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

7.8K
Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
7.8K
Vaccinations01:51

Vaccinations

49.1K
Overview
49.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A metabolic boost to mRNA vaccines.

Nature materials·2026
Same author

Photocontrolled immunotherapy: a BODIPY-caged MSA-2 for spatiotemporal activation of STING with visible light.

New journal of chemistry = Nouveau journal de chimie·2026
Same author

Lymphatic egress recycles tumor-experienced effector CD8 T cells to sustain immune surveillance.

bioRxiv : the preprint server for biology·2026
Same author

A tumor metabolism-angiogenesis-immune axis governs immunotherapy responses.

bioRxiv : the preprint server for biology·2026
Same author

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation.

Nature·2026
Same author

Chromatin architecture and physical constriction cooperate in phenotype switching and cancer cell dissemination.

bioRxiv : the preprint server for biology·2026

Related Experiment Video

Updated: Nov 11, 2025

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

3.8K

Building new roads to stronger immunity.

John T Wilson1, Amanda W Lund2

  • 1Department of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN 37212, USA. john.t.wilson@vanderbilt.edu amanda.lund@nyulangone.org.

Science Advances
|March 25, 2021
PubMed
Summary

A novel cancer vaccine technology enhances the immune system by creating lymphatic vessel networks. This approach significantly boosts the effectiveness of immunotherapy treatments for cancer.

More Related Videos

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
08:02

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

5.7K
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

10.8K

Related Experiment Videos

Last Updated: Nov 11, 2025

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus
13:00

Intranasal Immunization and Milk Collection in Studies of Maternal Immunization in New Zealand White Rabbits Oryctolagus cuniculus

Published on: July 31, 2021

3.8K
In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction
08:02

In Vivo Augmentation of Gut-Homing Regulatory T Cell Induction

Published on: January 22, 2020

5.7K
Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
06:32

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice

Published on: September 19, 2016

10.8K

Area of Science:

  • Oncology
  • Immunology
  • Biotechnology

Background:

  • Immunotherapy has revolutionized cancer treatment.
  • Enhancing the immune system's response remains a critical challenge.
  • Local immune responses are crucial for effective cancer vaccines.

Purpose of the Study:

  • To introduce a new cancer vaccine technology.
  • To investigate the role of lymphatic vessel networks in immunotherapy response.
  • To improve the efficacy of cancer immunotherapy.

Main Methods:

  • Development of a novel cancer vaccine.
  • Utilizing technology to build a network of local lymphatic vessels.
  • Assessing the impact on immune cell infiltration and activation.

Main Results:

  • The new vaccine technology successfully established a network of lymphatic vessels.
  • This network facilitated enhanced immune cell trafficking to the tumor site.
  • Stronger immune responses were observed, leading to improved immunotherapy outcomes.

Conclusions:

  • The developed cancer vaccine technology shows promise in enhancing immunotherapy.
  • Targeting lymphatic vessel formation is a viable strategy to improve anti-cancer immunity.
  • This approach offers a new avenue for developing more effective cancer vaccines.