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Updated: Jun 5, 2026
07:48
Spatial and Temporal Control of T Cell Activation Using a Photoactivatable Agonist
Published on: April 25, 2018
Photocontrolled immunotherapy: a BODIPY-caged MSA-2 for spatiotemporal activation of STING with visible light
Karan Arora1, Alexandra E Lee2, Neil C Chada2,3
1Department of Chemical and Biomolecular Engineering, Vanderbilt University Nashville Tennessee 37212 USA john.t.wilson@vanderbilt.edu karan.arora@vanderbilt.edu +1-615-322-6406.
New Journal of Chemistry = Nouveau Journal De Chimie
|June 4, 2026
Abstract:
The STING pathway is a promising target for cancer immunotherapy, but systemic activation by small-molecule agonists can cause adverse effects. We report a visible light-activatable STING agonist, BODIPY-MSA-2, enabling precise, light-dependent uncaging and restoration of STING activity in vitro, with potential to enable spatiotemporal control of immunostimulation.
