Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Proactive adoption of generative artificial intelligence (AI) in the operations of Japan's Pharmaceuticals and Medical Devices Agency (PMDA): Current initiatives, governance, and future perspectives.

Global health & medicine·2026
Same author

Digital Ischemia Following Radial Access Unmasking Systemic Sclerosis: Characteristic Intravascular Ultrasound Findings.

JACC. Case reports·2026
Same author

A multicenter, retrospective study in patients with multiple sclerosis treated with natalizumab in a real-world setting in Japan: The REFIND study.

Multiple sclerosis and related disorders·2026
Same author

Response to letter to the editor on "Preoperative treatment and postoperative outcomes in osteoporotic patients with vertebral fractures: a longitudinal database study".

Journal of bone and mineral metabolism·2025
Same author

Matrix metalloproteinase-1 and interleukin-17A are associated with previous plaque disruption: a combined proteomics and optical coherence tomography study.

Coronary artery disease·2025
Same author

Safety and Effectiveness of Satralizumab in Japanese Patients with Neuromyelitis Optica Spectrum Disorder: A 30‑Month Interim Analysis of Post‑marketing Surveillance.

Neurology and therapy·2025

Related Experiment Video

Updated: Nov 11, 2025

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
08:57

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Published on: March 26, 2015

27.4K

[Tumefactive demyelinating lesion (TDL)].

Akihiro Nakajima1, Izumi Kawachi

  • 1Department of Neurology, Brain Research Institute, Niigata University.

No Shinkei Geka. Neurological Surgery
|March 25, 2021
PubMed
Summary

Tumefactive demyelinating lesions (TDLs) are large brain lesions requiring careful diagnosis. Identifying the underlying cause, such as multiple sclerosis or neuromyelitis optica spectrum disorder, is crucial for effective treatment.

Area of Science:

  • Neurology
  • Radiology
  • Immunology

Background:

  • Tumefactive demyelinating lesions (TDLs) are large (>2 cm) brain lesions presenting with mass effect and edema.
  • TDLs can be associated with various conditions, including multiple sclerosis (MS), neuromyelitis optica spectrum disorder (NMOSD), and acute disseminated encephalomyelitis (ADEM).

Purpose of the Study:

  • To highlight the diagnostic challenges and considerations for tumefactive demyelinating lesions.
  • To emphasize the importance of differentiating TDLs based on their underlying etiology for appropriate management.

Main Methods:

  • Review of radiological findings on MRI, including size, mass effect, edema, and enhancement patterns.
  • Discussion of non-invasive diagnostic methods like MR imaging and autoantibody assays (e.g., aquaporin-4 antibodies).

More Related Videos

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.7K
Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
08:40

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

4.3K

Related Experiment Videos

Last Updated: Nov 11, 2025

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin
08:57

Experimental Demyelination and Remyelination of Murine Spinal Cord by Focal Injection of Lysolecithin

Published on: March 26, 2015

27.4K
Comprehensive Autopsy Program for Individuals with Multiple Sclerosis
09:41

Comprehensive Autopsy Program for Individuals with Multiple Sclerosis

Published on: July 19, 2019

11.7K
Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
08:40

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis

Published on: February 28, 2021

4.3K
  • Consideration of brain biopsy for atypical presentations to exclude alternative pathologies like primary central nervous system lymphoma.

    • Main Results:

    • Radiological hallmarks of TDLs on MRI include large size, mass effect, perilesional edema, T2 hypointense rim, peripheral diffusion restriction, open ring enhancement, vascular enhancement, and the central vein sign.
    • Diagnostic workup involves MR imaging and autoantibody testing.
    • Brain biopsy may be necessary in complex cases.

    Conclusions:

    • Accurate diagnosis of TDLs requires a comprehensive approach, integrating clinical, radiological, and serological data.
    • Distinguishing the specific etiology of TDLs is paramount as treatments and prognoses vary significantly among conditions like MS, NMOSD, and ADEM.