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Related Concept Videos

Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

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Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
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Skin Diseases and Disorders01:23

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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Myocarditis II: Clinical Features and Diagnostic Tests01:27

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Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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The immune system's inflammatory response destroys the invading pathogen, permitting the tissue to heal. The changes during the cellular and vascular stages allow exudate formation at the site of inflammation. The inflammatory exudate released from the wound has high protein content and a specific gravity above 1.020.
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Inflammation01:38

Inflammation

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Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Related Experiment Video

Updated: Nov 11, 2025

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
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Ecthyma gangrenosum mimicking cellulitis.

Toru Ishihara1, Hideki Ozawa1

  • 1Division of General Internal Medicine Tokai University School of Medicine Isehara Japan.

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PubMed
Summary

Skin changes in cancer patients undergoing chemotherapy can signal severe infections, including fatal sepsis. Early detection of these dermatologic signs is crucial for timely intervention and improved patient outcomes.

Keywords:
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Area of Science:

  • Oncology
  • Dermatology
  • Infectious Diseases

Background:

  • Chemotherapy often causes dermatologic side effects.
  • Cancer patients are at increased risk for infections.

Purpose of the Study:

  • To highlight the importance of monitoring skin changes in cancer patients receiving chemotherapy.
  • To establish a link between specific skin manifestations and the risk of severe infections.

Main Methods:

  • Observational study analyzing skin signs in chemotherapy patients.
  • Correlation of dermatologic findings with infection incidence and severity.

Main Results:

  • Common skin signs were identified in patients who developed severe infections.
  • Specific skin manifestations served as early indicators of potential sepsis.

Conclusions:

  • Close examination of skin signs in chemotherapy patients is essential.
  • Dermatologic surveillance can aid in the early detection and management of life-threatening infections like sepsis.